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学科主题: 物理化学
题名: Serum Metabolomics Study and Eicosanoid Analysis of Childhood Atopic Dermatitis Based on Liquid Chromatography-Mass Spectrometry
作者: Huang, Yan1;  Chen, Guoyou2, 3;  Liu, Xinyu2;  Shao, Yaping2;  Gao, Peng2;  Xin, Chenchen1;  Cui, Zhenze1;  Zhao, Xinjie2;  Xu, Guowang2
通讯作者: 赵欣捷
关键词: Atopic dermatitis ;  metabolomics ;  eicosanoids ;  immunoglobulin E ;  LC-MS
刊名: JOURNAL OF PROTEOME RESEARCH
发表日期: 2014-12-01
DOI: 10.1021/pr5007069
卷: 13, 期:12, 页:5715-5723
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemical Research Methods
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: Atopic dermatitis (AD) is the most common inflammatory skin disease in children. In the study, ultra high performance liquid chromatographymass spectrometry was used to investigate serum metabolic abnormalities of AD children. Two batch fasting sera were collected from AD children and healthy control; one of them was for nontargeted metabolomics analysis, the other for targeted eicosanoids analysis. AD children were divided into high immunoglobulin E (IgE) group and normal IgE group. On the basis of the two analysis approaches, it was found that the differential metabolites of AD, leukotriene B4, prostaglandins, conjugated bile acids, etc., were associated with inflammatory response and bile acids metabolism. Carnitines, free fatty acids, lactic acid, etc., increased in the AD group with high IgE, which revealed energy metabolism disorder. Amino acid metabolic abnormalities and increased levels of Cytochrome P450 epoxygenase metabolites were found in the AD group with normal IgE. The results provided a new perspective to understand the mechanism and find potential biomarkers of AD and may provide a new reference for personalized treatment.
关键词[WOS]: STRATUM-CORNEUM LIPIDS ;  CHAIN AMINO-ACIDS ;  NITRIC-OXIDE ;  ARACHIDONIC-ACID ;  MITOCHONDRIAL DYSFUNCTION ;  INTESTINAL INFLAMMATION ;  SKIN INFLAMMATION ;  DISEASE ;  POLYMORPHISMS ;  ACCUMULATION
语种: 英语
WOS记录号: WOS:000346039400037
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144196
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Childrens Hosp, Dalian 116011, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Harbin Med Univ, Dept Pharm, Daqing 163319, Peoples R China

Recommended Citation:
Huang, Yan,Chen, Guoyou,Liu, Xinyu,et al. Serum Metabolomics Study and Eicosanoid Analysis of Childhood Atopic Dermatitis Based on Liquid Chromatography-Mass Spectrometry[J]. JOURNAL OF PROTEOME RESEARCH,2014,13(12):5715-5723.
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