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学科主题: 物理化学
题名: Current state-of-the-art of nontargeted metabolomics based on liquid chromatography-mass spectrometry with special emphasis in clinical applications
作者: Yin, Peiyuan1;  Xu, Guowang1
通讯作者: 许国旺
关键词: Metabolomics ;  Metabolic profiling ;  LC-MS ;  Metabolite coverage ;  Pseudo-targeted method
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2014-12-29
DOI: 10.1016/j.chroma.2014.11.050
卷: 1374, 期:1, 页:1-13
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Metabolomics, as a part of systems biology, has been widely applied in different fields of life science by studying the endogenous metabolites. The development and applications of liquid chromatography (LC) coupled with high resolution mass spectrometry (MS) greatly improve the achievable data quality in non-targeted metabolic profiling. However, there are still some emerging challenges to be covered in LC-MS based metabolomics. Here, recent approaches about sample collection and preparation, instrumental analysis, and data handling of LC-MS based metabolomics are summarized, especially in the analysis of clinical samples. Emphasis is put on the improvement of analytical techniques including the combination of different LC columns, isotope coded derivatization methods, pseudo-targeted LC-MS method, new data analysis algorithms and structural identification of important metabolites. (C) 2014 Elsevier B.V. All rights reserved.
关键词[WOS]: SOLID-PHASE MICROEXTRACTION ;  MS-BASED METABOLOMICS ;  GESTATIONAL DIABETES-MELLITUS ;  FUNCTIONAL GENOMICS TOOL ;  GLOBAL SYSTEMS BIOLOGY ;  HUMAN BLOOD-PLASMA ;  TERT-BUTYL ETHER ;  LC-MS ;  METABOLITE IDENTIFICATION ;  SAMPLE PREPARATION
语种: 英语
WOS记录号: WOS:000347605000001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144198
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

Recommended Citation:
Yin, Peiyuan,Xu, Guowang. Current state-of-the-art of nontargeted metabolomics based on liquid chromatography-mass spectrometry with special emphasis in clinical applications[J]. JOURNAL OF CHROMATOGRAPHY A,2014,1374(1):1-13.
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