DICP OpenIR
Subject Area物理化学
Current state-of-the-art of nontargeted metabolomics based on liquid chromatography-mass spectrometry with special emphasis in clinical applications
Yin, Peiyuan; Xu, Guowang; Xu GW(许国旺)
KeywordMetabolomics Metabolic Profiling Lc-ms Metabolite Coverage Pseudo-targeted Method
Source PublicationJOURNAL OF CHROMATOGRAPHY A
2014-12-29
DOI10.1016/j.chroma.2014.11.050
Volume1374Issue:1Pages:1-13
Indexed BySCI
SubtypeReview
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordSOLID-PHASE MICROEXTRACTION ; MS-BASED METABOLOMICS ; GESTATIONAL DIABETES-MELLITUS ; FUNCTIONAL GENOMICS TOOL ; GLOBAL SYSTEMS BIOLOGY ; HUMAN BLOOD-PLASMA ; TERT-BUTYL ETHER ; LC-MS ; METABOLITE IDENTIFICATION ; SAMPLE PREPARATION
AbstractMetabolomics, as a part of systems biology, has been widely applied in different fields of life science by studying the endogenous metabolites. The development and applications of liquid chromatography (LC) coupled with high resolution mass spectrometry (MS) greatly improve the achievable data quality in non-targeted metabolic profiling. However, there are still some emerging challenges to be covered in LC-MS based metabolomics. Here, recent approaches about sample collection and preparation, instrumental analysis, and data handling of LC-MS based metabolomics are summarized, especially in the analysis of clinical samples. Emphasis is put on the improvement of analytical techniques including the combination of different LC columns, isotope coded derivatization methods, pseudo-targeted LC-MS method, new data analysis algorithms and structural identification of important metabolites. (C) 2014 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000347605000001
Citation statistics
Cited Times:54[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/144198
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu GW(许国旺)
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Yin, Peiyuan,Xu, Guowang,Xu GW. Current state-of-the-art of nontargeted metabolomics based on liquid chromatography-mass spectrometry with special emphasis in clinical applications[J]. JOURNAL OF CHROMATOGRAPHY A,2014,1374(1):1-13.
APA Yin, Peiyuan,Xu, Guowang,&许国旺.(2014).Current state-of-the-art of nontargeted metabolomics based on liquid chromatography-mass spectrometry with special emphasis in clinical applications.JOURNAL OF CHROMATOGRAPHY A,1374(1),1-13.
MLA Yin, Peiyuan,et al."Current state-of-the-art of nontargeted metabolomics based on liquid chromatography-mass spectrometry with special emphasis in clinical applications".JOURNAL OF CHROMATOGRAPHY A 1374.1(2014):1-13.
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