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学科主题物理化学
Preparation of Monolithic Polymer Columns with Homogeneous Structure via Photoinitiated Thiol-yne Click Polymerization and Their Application in Separation of Small Molecules
Liu, Zhongshan1,2; Ou, Junjie1; Lin, Hui1,2; Wang, Hongwei1; Liu, Zheyi1,2; Dong, Jing1; Zou, Hanfa1; Ou JJ(欧俊杰); Zou HF(邹汉法)
刊名ANALYTICAL CHEMISTRY
2014-12-16
DOI10.1021/ac503626v
86期:24页:12334-12340
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; POLYHEDRAL OLIGOMERIC SILSESQUIOXANE ; RING-OPENING POLYMERIZATION ; CAPILLARY ELECTROCHROMATOGRAPHY ; STATIONARY PHASES ; ENE CHEMISTRY ; SILICA ; MORPHOLOGY ; EFFICIENT ; PHOTOPOLYMERIZATION
英文摘要Two monolithic polymer columns were directly prepared in the UV-transparent fused-silica capillaries via photoinitiated thiol-yne click polymerization of 1,7-octadiyne (ODY) with a dithiol (1,6-hexanedithiol, 2SH) or a tetrathiol (pentaerythriol tetrakis(3-mercaptopropionate), 4SH) within 15 min. The rapid polymerization provided a time-saving approach to optimize preparation conditions. Then, two porogenic systems of diethylene glycol diethyl ether (DEGDE)/tetrahydrofuran (THF) and DEGDE/poly(ethylene glycol) (PEG, Mn = 200) were found to effectively control the porous structure of two kinds of polymeric monoliths (O2SH and O4SH), respectively. The almost disappearance of thiol and alkynyl vibrations (2560 and 2115 cm(-1), respectively) in infrared spectra and Raman spectra indicated a high conversion of the thiol-yne polymerization reaction. The thiol-yne polymerization was further proved by analyzing the energy-dispersive X-ray spectrum (EDS), MALDI-TOF mass spectrum, and elemental data. Scanning electron microscopy (SEM) images showed the monolithic polymer columns with homogeneous porous structure and macropore size of 0.5-1.0 mu m, which facilitated the minimum plate heights of 10.0-12.0 mum for alkylbenzenes in reversed-phase liquid chromatography (RPLC). The low values of the A and C terms (<1.0 mu m and <15.5 ms, respectively) in the van Deemter equation were similar to those obtained by some monolithic silica columns. The BSA tryptic digest was also separated on the monolithic polymer column by cLC-MS/MS. The result with 85% protein coverage was better than those given by some hybrid monolithic columns. The monolithic polymer columns were further applied for separation of phenols, natural products, and standard proteins and demonstrated satisfactory separation ability.
语种英语
WOS记录号WOS:000346683900061
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/144257
专题中国科学院大连化学物理研究所
通讯作者Ou JJ(欧俊杰); Zou HF(邹汉法)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Liu, Zhongshan,Ou, Junjie,Lin, Hui,et al. Preparation of Monolithic Polymer Columns with Homogeneous Structure via Photoinitiated Thiol-yne Click Polymerization and Their Application in Separation of Small Molecules[J]. ANALYTICAL CHEMISTRY,2014,86(24):12334-12340.
APA Liu, Zhongshan.,Ou, Junjie.,Lin, Hui.,Wang, Hongwei.,Liu, Zheyi.,...&邹汉法.(2014).Preparation of Monolithic Polymer Columns with Homogeneous Structure via Photoinitiated Thiol-yne Click Polymerization and Their Application in Separation of Small Molecules.ANALYTICAL CHEMISTRY,86(24),12334-12340.
MLA Liu, Zhongshan,et al."Preparation of Monolithic Polymer Columns with Homogeneous Structure via Photoinitiated Thiol-yne Click Polymerization and Their Application in Separation of Small Molecules".ANALYTICAL CHEMISTRY 86.24(2014):12334-12340.
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