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学科主题: 物理化学
题名: Amide Alkaloids from Scopolia tangutica
作者: Long, Zhen1;  Zhang, Yan2;  Guo, Zhimou1;  Wang, Lien2;  Xue, Xingya1;  Zhang, Xiuli1;  Wang, Shisheng3;  Wang, Zhiwei2;  Civelli, Olivier2;  Liang, Xinmiao1
通讯作者: 梁鑫淼 ;  张秀莉
关键词: Scopolia tangutica ;  Solanaceae ;  alkaloid ;  hydroxycinnamic acid amide ;  mu-opioid receptor
刊名: PLANTA MEDICA
发表日期: 2014-08-01
DOI: 10.1055/s-0034-1382961
卷: 80, 期:13, 页:1124-1130
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy
英文摘要: Four new hydroxycinnamic acid amides, scotanamines A-D (1-4), and seven known alkaloids, including N-1,N-10-di-dihydrocaffeoylspermidine (5), scopolamine (6), anisodamine (7), hyoscyamine (8), anisodine (9), caffeoylputrescine (10), and N-1-caffeoyl-N-3-dihydrocaffeoylspermidine (11), were obtained from the roots of Scopolia tangutica. The present study represents the first recognition of hydroxycinnamic acid amides containing putrescine or spermidine in S. tangutica. Compound 1, in particular, contains a moiety resulting from the condensation of nortropinone and putrescine. Compound 2 exhibited moderate agonist activity at the mu-opioid receptor (EC50 = 7.3 mu M). Compound 2 was tested in vivo and induced analgesia in mice. The analgesic effect was recorded using the tail-flick assay and was reversed by naloxone.
关键词[WOS]: PHENOLIC-COMPOUNDS ;  TROPANE ALKALOIDS ;  NICOTIANA-TABACUM ;  LYCIUM-CHINENSE ;  CAFFEOYLPUTRESCINE ;  ANISODAMINE ;  SPECTROSCOPY ;  SCOPOLAMINE ;  PAIN
语种: 英语
WOS记录号: WOS:000341581600010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144341
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作者单位: 1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Key Lab Nat Med, Dalian 116023, Peoples R China
2.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA
3.Dalian Univ Technol, Sch Pharmaceut Sci & Technol, Dalian, Peoples R China

Recommended Citation:
Long, Zhen,Zhang, Yan,Guo, Zhimou,et al. Amide Alkaloids from Scopolia tangutica[J]. PLANTA MEDICA,2014,80(13):1124-1130.
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