DICP OpenIR
学科主题物理化学
Amide Alkaloids from Scopolia tangutica
Long, Zhen1; Zhang, Yan2; Guo, Zhimou1; Wang, Lien2; Xue, Xingya1; Zhang, Xiuli1; Wang, Shisheng3; Wang, Zhiwei2; Civelli, Olivier2; Liang, Xinmiao1; Liang XM(梁鑫淼); Zhang XL(张秀莉)
关键词Scopolia Tangutica Solanaceae Alkaloid Hydroxycinnamic Acid Amide Mu-opioid Receptor
刊名PLANTA MEDICA
2014-08-01
DOI10.1055/s-0034-1382961
80期:13页:1124-1130
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]PHENOLIC-COMPOUNDS ; TROPANE ALKALOIDS ; NICOTIANA-TABACUM ; LYCIUM-CHINENSE ; CAFFEOYLPUTRESCINE ; ANISODAMINE ; SPECTROSCOPY ; SCOPOLAMINE ; PAIN
英文摘要Four new hydroxycinnamic acid amides, scotanamines A-D (1-4), and seven known alkaloids, including N-1,N-10-di-dihydrocaffeoylspermidine (5), scopolamine (6), anisodamine (7), hyoscyamine (8), anisodine (9), caffeoylputrescine (10), and N-1-caffeoyl-N-3-dihydrocaffeoylspermidine (11), were obtained from the roots of Scopolia tangutica. The present study represents the first recognition of hydroxycinnamic acid amides containing putrescine or spermidine in S. tangutica. Compound 1, in particular, contains a moiety resulting from the condensation of nortropinone and putrescine. Compound 2 exhibited moderate agonist activity at the mu-opioid receptor (EC50 = 7.3 mu M). Compound 2 was tested in vivo and induced analgesia in mice. The analgesic effect was recorded using the tail-flick assay and was reversed by naloxone.
语种英语
WOS记录号WOS:000341581600010
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/144341
专题中国科学院大连化学物理研究所
通讯作者Liang XM(梁鑫淼); Zhang XL(张秀莉)
作者单位1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Key Lab Nat Med, Dalian 116023, Peoples R China
2.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA
3.Dalian Univ Technol, Sch Pharmaceut Sci & Technol, Dalian, Peoples R China
推荐引用方式
GB/T 7714
Long, Zhen,Zhang, Yan,Guo, Zhimou,et al. Amide Alkaloids from Scopolia tangutica[J]. PLANTA MEDICA,2014,80(13):1124-1130.
APA Long, Zhen.,Zhang, Yan.,Guo, Zhimou.,Wang, Lien.,Xue, Xingya.,...&张秀莉.(2014).Amide Alkaloids from Scopolia tangutica.PLANTA MEDICA,80(13),1124-1130.
MLA Long, Zhen,et al."Amide Alkaloids from Scopolia tangutica".PLANTA MEDICA 80.13(2014):1124-1130.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2014aiZAJKhirv.PDF(276KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Long, Zhen]的文章
[Zhang, Yan]的文章
[Guo, Zhimou]的文章
百度学术
百度学术中相似的文章
[Long, Zhen]的文章
[Zhang, Yan]的文章
[Guo, Zhimou]的文章
必应学术
必应学术中相似的文章
[Long, Zhen]的文章
[Zhang, Yan]的文章
[Guo, Zhimou]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。