DICP OpenIR
Subject Area物理化学
Amide Alkaloids from Scopolia tangutica
Long, Zhen1; Zhang, Yan2; Guo, Zhimou1; Wang, Lien2; Xue, Xingya1; Zhang, Xiuli1; Wang, Shisheng3; Wang, Zhiwei2; Civelli, Olivier2; Liang, Xinmiao1; Liang XM(梁鑫淼); Zhang XL(张秀莉)
KeywordScopolia Tangutica Solanaceae Alkaloid Hydroxycinnamic Acid Amide Mu-opioid Receptor
Source PublicationPLANTA MEDICA
2014-08-01
DOI10.1055/s-0034-1382961
Volume80Issue:13Pages:1124-1130
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS KeywordPHENOLIC-COMPOUNDS ; TROPANE ALKALOIDS ; NICOTIANA-TABACUM ; LYCIUM-CHINENSE ; CAFFEOYLPUTRESCINE ; ANISODAMINE ; SPECTROSCOPY ; SCOPOLAMINE ; PAIN
AbstractFour new hydroxycinnamic acid amides, scotanamines A-D (1-4), and seven known alkaloids, including N-1,N-10-di-dihydrocaffeoylspermidine (5), scopolamine (6), anisodamine (7), hyoscyamine (8), anisodine (9), caffeoylputrescine (10), and N-1-caffeoyl-N-3-dihydrocaffeoylspermidine (11), were obtained from the roots of Scopolia tangutica. The present study represents the first recognition of hydroxycinnamic acid amides containing putrescine or spermidine in S. tangutica. Compound 1, in particular, contains a moiety resulting from the condensation of nortropinone and putrescine. Compound 2 exhibited moderate agonist activity at the mu-opioid receptor (EC50 = 7.3 mu M). Compound 2 was tested in vivo and induced analgesia in mice. The analgesic effect was recorded using the tail-flick assay and was reversed by naloxone.
Language英语
WOS IDWOS:000341581600010
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/144341
Collection中国科学院大连化学物理研究所
Corresponding AuthorLiang XM(梁鑫淼); Zhang XL(张秀莉)
Affiliation1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Key Lab Nat Med, Dalian 116023, Peoples R China
2.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA
3.Dalian Univ Technol, Sch Pharmaceut Sci & Technol, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Long, Zhen,Zhang, Yan,Guo, Zhimou,et al. Amide Alkaloids from Scopolia tangutica[J]. PLANTA MEDICA,2014,80(13):1124-1130.
APA Long, Zhen.,Zhang, Yan.,Guo, Zhimou.,Wang, Lien.,Xue, Xingya.,...&张秀莉.(2014).Amide Alkaloids from Scopolia tangutica.PLANTA MEDICA,80(13),1124-1130.
MLA Long, Zhen,et al."Amide Alkaloids from Scopolia tangutica".PLANTA MEDICA 80.13(2014):1124-1130.
Files in This Item:
File Name/Size DocType Version Access License
2014aiZAJKhirv.PDF(276KB)期刊论文作者接受稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Long, Zhen]'s Articles
[Zhang, Yan]'s Articles
[Guo, Zhimou]'s Articles
Baidu academic
Similar articles in Baidu academic
[Long, Zhen]'s Articles
[Zhang, Yan]'s Articles
[Guo, Zhimou]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Long, Zhen]'s Articles
[Zhang, Yan]'s Articles
[Guo, Zhimou]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.