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学科主题: 物理化学
题名: Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons
作者: Wang, Cai-Ping1;  Li, Gui-Cai1;  Shi, Yun-Wei1;  Zhang, Xiao-Chuan1;  Li, Jian-Long1;  Wang, Zhi-Wei1, 2;  Ding, Fei1;  Liang, Xin-Miao1, 3
通讯作者: ZhiweiWang ;  FeiDing ;  梁鑫淼
关键词: Schizandrin A ;  Apoptosis ;  Ischemia ;  Mitogen-activated protein kinase (MAPK) ;  C5aR
刊名: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
发表日期: 2014-09-01
DOI: 10.1007/s13105-014-0342-3
卷: 70, 期:3, 页:735-747
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Physiology
研究领域[WOS]: Biochemistry & Molecular Biology ;  Physiology
英文摘要: Brain ischemia appears to be associated with innate immunity. Recent reports showed that C3a and C5a, as potent targets, might protect against ischemia induced cell death. In traditional Chinese medicine, the fruit of Schizandra chinesis Baill (Fructus schizandrae) has been widely used as a tonic. In the present study, we sought to evaluate the neuroprotective effects of schizandrin A, a composition of S. chinesis Baill, against oxygen and glucose deprivation followed by reperfusion (OGD/R)-induced cell death in primary culture of rat cortical neurons, and to test whether C3a and C5a affected cortical neuron recovery from ischemic injury after schizandrin A treatment. The results showed that schizandrin A significantly reduced cell apoptosis and necrosis, increased cell survival, and decreased intracellular calcium concentration ([Ca2+](i)) and lactate dehydrogenase (LDH) release in primary culture of rat cortical neurons after OGD/R. Mechanism studies suggested that the modulation of extracellular-regulated kinase (ERK), c-Jun NH2-terminal kinases (JNK), and p38, as well as caspase-3 activity played an important role on the progress of neuronal apoptosis. C5aR participated in the neuroprotective effect of schizandrin A in primary culture of rat cortical neurons after OGD/R. Our findings suggested that schizandrin A might act as a candidate therapeutic target drug used for brain ischemia and related diseases.
关键词[WOS]: ISCHEMIC BRAIN-INJURY ;  ACTIVATED PROTEIN-KINASE ;  SIGNAL-TRANSDUCTION ;  APOPTOSIS ;  COMPLEMENT ;  C5A ;  PATHWAY ;  STROKE ;  NEURODEGENERATION ;  DEPRIVATION
语种: 英语
WOS记录号: WOS:000342070000008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144343
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Peoples R China
2.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Wang, Cai-Ping,Li, Gui-Cai,Shi, Yun-Wei,et al. Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons[J]. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY,2014,70(3):735-747.
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