Knowledge Commons of Dalian Institute of Chemical Physics, CAS
| Subject Area | 物理化学 |
| Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons | |
| Wang, Cai-Ping1; Li, Gui-Cai1; Shi, Yun-Wei1; Zhang, Xiao-Chuan1; Li, Jian-Long1; Wang, Zhi-Wei1,2; Ding, Fei1; Liang, Xin-Miao1,3; ZhiweiWang; FeiDing; Liang XM(梁鑫淼) | |
| Keyword | Schizandrin a Apoptosis Ischemia Mitogen-activated Protein Kinase (Mapk) C5ar |
| Source Publication | JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
 |
| 2014-09-01 | |
| DOI | 10.1007/s13105-014-0342-3 |
| Volume | 70Issue:3Pages:735-747 |
| Indexed By | SCI |
| Subtype | Article |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| WOS Subject | Biochemistry & Molecular Biology ; Physiology |
| WOS Research Area | Biochemistry & Molecular Biology ; Physiology |
| WOS Keyword | ISCHEMIC BRAIN-INJURY ; ACTIVATED PROTEIN-KINASE ; SIGNAL-TRANSDUCTION ; APOPTOSIS ; COMPLEMENT ; C5A ; PATHWAY ; STROKE ; NEURODEGENERATION ; DEPRIVATION |
| Abstract | Brain ischemia appears to be associated with innate immunity. Recent reports showed that C3a and C5a, as potent targets, might protect against ischemia induced cell death. In traditional Chinese medicine, the fruit of Schizandra chinesis Baill (Fructus schizandrae) has been widely used as a tonic. In the present study, we sought to evaluate the neuroprotective effects of schizandrin A, a composition of S. chinesis Baill, against oxygen and glucose deprivation followed by reperfusion (OGD/R)-induced cell death in primary culture of rat cortical neurons, and to test whether C3a and C5a affected cortical neuron recovery from ischemic injury after schizandrin A treatment. The results showed that schizandrin A significantly reduced cell apoptosis and necrosis, increased cell survival, and decreased intracellular calcium concentration ([Ca2+](i)) and lactate dehydrogenase (LDH) release in primary culture of rat cortical neurons after OGD/R. Mechanism studies suggested that the modulation of extracellular-regulated kinase (ERK), c-Jun NH2-terminal kinases (JNK), and p38, as well as caspase-3 activity played an important role on the progress of neuronal apoptosis. C5aR participated in the neuroprotective effect of schizandrin A in primary culture of rat cortical neurons after OGD/R. Our findings suggested that schizandrin A might act as a candidate therapeutic target drug used for brain ischemia and related diseases. |
| Language | 英语 |
| WOS ID | WOS:000342070000008 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://cas-ir.dicp.ac.cn/handle/321008/144343 |
| Collection | 中国科学院大连化学物理研究所 |
| Corresponding Author | ZhiweiWang; FeiDing; Liang XM(梁鑫淼) |
| Affiliation | 1.Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Peoples R China 2.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Cai-Ping,Li, Gui-Cai,Shi, Yun-Wei,et al. Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons[J]. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY,2014,70(3):735-747. |
| APA | Wang, Cai-Ping.,Li, Gui-Cai.,Shi, Yun-Wei.,Zhang, Xiao-Chuan.,Li, Jian-Long.,...&梁鑫淼.(2014).Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons.JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY,70(3),735-747. |
| MLA | Wang, Cai-Ping,et al."Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons".JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY 70.3(2014):735-747. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2014Xwwu644GLh.PDF（796KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | Application Full Text | |
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