DICP OpenIR
Subject Area物理化学
Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons
Wang, Cai-Ping1; Li, Gui-Cai1; Shi, Yun-Wei1; Zhang, Xiao-Chuan1; Li, Jian-Long1; Wang, Zhi-Wei1,2; Ding, Fei1; Liang, Xin-Miao1,3; ZhiweiWang; FeiDing; Liang XM(梁鑫淼)
KeywordSchizandrin a Apoptosis Ischemia Mitogen-activated Protein Kinase (Mapk) C5ar
Source PublicationJOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
2014-09-01
DOI10.1007/s13105-014-0342-3
Volume70Issue:3Pages:735-747
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemistry & Molecular Biology ; Physiology
WOS Research AreaBiochemistry & Molecular Biology ; Physiology
WOS KeywordISCHEMIC BRAIN-INJURY ; ACTIVATED PROTEIN-KINASE ; SIGNAL-TRANSDUCTION ; APOPTOSIS ; COMPLEMENT ; C5A ; PATHWAY ; STROKE ; NEURODEGENERATION ; DEPRIVATION
AbstractBrain ischemia appears to be associated with innate immunity. Recent reports showed that C3a and C5a, as potent targets, might protect against ischemia induced cell death. In traditional Chinese medicine, the fruit of Schizandra chinesis Baill (Fructus schizandrae) has been widely used as a tonic. In the present study, we sought to evaluate the neuroprotective effects of schizandrin A, a composition of S. chinesis Baill, against oxygen and glucose deprivation followed by reperfusion (OGD/R)-induced cell death in primary culture of rat cortical neurons, and to test whether C3a and C5a affected cortical neuron recovery from ischemic injury after schizandrin A treatment. The results showed that schizandrin A significantly reduced cell apoptosis and necrosis, increased cell survival, and decreased intracellular calcium concentration ([Ca2+](i)) and lactate dehydrogenase (LDH) release in primary culture of rat cortical neurons after OGD/R. Mechanism studies suggested that the modulation of extracellular-regulated kinase (ERK), c-Jun NH2-terminal kinases (JNK), and p38, as well as caspase-3 activity played an important role on the progress of neuronal apoptosis. C5aR participated in the neuroprotective effect of schizandrin A in primary culture of rat cortical neurons after OGD/R. Our findings suggested that schizandrin A might act as a candidate therapeutic target drug used for brain ischemia and related diseases.
Language英语
WOS IDWOS:000342070000008
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/144343
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhiweiWang; FeiDing; Liang XM(梁鑫淼)
Affiliation1.Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Peoples R China
2.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Wang, Cai-Ping,Li, Gui-Cai,Shi, Yun-Wei,et al. Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons[J]. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY,2014,70(3):735-747.
APA Wang, Cai-Ping.,Li, Gui-Cai.,Shi, Yun-Wei.,Zhang, Xiao-Chuan.,Li, Jian-Long.,...&梁鑫淼.(2014).Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons.JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY,70(3),735-747.
MLA Wang, Cai-Ping,et al."Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons".JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY 70.3(2014):735-747.
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