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学科主题: 物理化学
题名: Label-free quantification of differentially expressed proteins in mouse liver cancer cells with high and low metastasis rates by a SWATH acquisition method
作者: Yan ZiQi1;  Zhou Yuan1;  Shan YiChu1;  Wu Qi1;  Zhang Shen1;  Liang Zhen1;  Zhang LiHua1;  Zhang YuKui1
通讯作者: 张丽华
关键词: label-free quantification ;  SWATH acquisition ;  differentially expressed protein ;  liver cancer ;  metastasis rate
刊名: SCIENCE CHINA-CHEMISTRY
发表日期: 2014-05-01
DOI: 10.1007/s11426-014-5093-z
卷: 57, 期:5, 页:718-722
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Label-free quantification is a valuable tool for the analysis of differentially expressed proteins identified by mass spectrometry methods. Herein, we used a new strategy: data-dependent acquisition mode identification combined with label-free quantification by SWATH acquisition mode, to study the differentially expressed proteins in mouse liver cancer metastasis cells. A total of 1528 protein groups were identified, among which 1159 protein groups were quantified and 249 protein groups were observed as differentially expressed proteins (86 proteins up-regulated and 163 down-regulated). This method provides a commendable solution for the identification and quantification of differentially expressed proteins in biological samples.
关键词[WOS]: TANDEM MASS-SPECTROMETRY ;  LYMPHATIC METASTASIS ;  SHOTGUN PROTEOMICS ;  PLASMA-PROTEINS ;  BIOMARKER ;  IDENTIFICATION ;  CARCINOMA ;  SPECTRA ;  LINES ;  MS
语种: 英语
WOS记录号: WOS:000335735200009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144438
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

Recommended Citation:
Yan ZiQi,Zhou Yuan,Shan YiChu,et al. Label-free quantification of differentially expressed proteins in mouse liver cancer cells with high and low metastasis rates by a SWATH acquisition method[J]. SCIENCE CHINA-CHEMISTRY,2014,57(5):718-722.
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