中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
学科主题: 物理化学
题名: Gd-Al co-doped mesoporous silica nanoparticles loaded with Ru(bpy)(3)(2+) as a dual-modality probe for fluorescence and magnetic resonance imaging
作者: Zhang, Dan1, 2;  Gao, Ai1, 2;  Xu, Yang1, 2;  Yin, Xue-Bo1, 2;  He, Xi-Wen1, 2;  Zhang, Yu-Kui1, 2, 3
通讯作者: XueboYin
刊名: ANALYST
发表日期: 2014-09-21
DOI: 10.1039/c4an00816b
卷: 139, 期:18, 页:4613-4619
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Mesoporous silica nanoparticles (MSNs) were co-doped with Gd3+ and Al3+ and then loaded with Ru(bpy)(3)(2+) by ion-exchange to prepare Ru/Gd-Al@MSNs. The as-prepared Ru/Gd-Al@MSNs were applied as contrast agents for in vivo fluorescence and magnetic resonance (MR) dual-modality imaging with a mouse as a model. The effects of Al3+ and MSNs on longitudinal relaxivity (r(1)) and fluorescence were investigated using a series of Gd-containing silica nanoparticles, including Gd@MSNs, Gd-Al@MSNs, and Ru/Gd-Al@nonporous silica nanoparticles. Co-doping with Al3+ improved the loading of Gd3+; the mesoporous structure improved the water exchange rate. The improvement enhanced the MR imaging efficiency of the Ru/Gd-Al@MSN probe. A higher relaxivity (19.2 mM(-1) s(-1)) was observed compared to that from a commercial contrast agent, Gd-diethylene triamine pentaacetic acid (GdDTPA). Importantly, the mesoporous structure provided a large specific surface area for the loading of Ru(bpy)(3)(2+) by a simple ion-exchange procedure. Intense red fluorescence was observed from Ru/Gd-Al@MSN probes. The versatility of Ru/Gd-Al@MSNs for dual-modality imaging was demonstrated using in vivo fluorescence imaging and T-1-weighted MR imaging with a mouse model. The nanoparticles are biocompatible and may be attractive for clinical applications.
关键词[WOS]: CONTRAST AGENTS ;  SUSPENSIONS ;  PARTICLES ;  TOXICITY ;  MICE
语种: 英语
WOS记录号: WOS:000340755000028
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144452
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2014ePrG5Y18Rd.PDF(1346KB)期刊论文作者接受稿开放获取View Download

作者单位: 1.Nankai Univ, Coll Chem, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Nankai Univ, Coll Chem, Res Ctr Analyt Sci, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Nat Chromatog R&A Ctr, Dalian Inst Chem Phys, Dalian 116011, Peoples R China

Recommended Citation:
Zhang, Dan,Gao, Ai,Xu, Yang,et al. Gd-Al co-doped mesoporous silica nanoparticles loaded with Ru(bpy)(3)(2+) as a dual-modality probe for fluorescence and magnetic resonance imaging[J]. ANALYST,2014,139(18):4613-4619.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Zhang, Dan]'s Articles
 [Gao, Ai]'s Articles
 [Xu, Yang]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Zhang, Dan]‘s Articles
 [Gao, Ai]‘s Articles
 [Xu, Yang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
文件名: 2014ePrG5Y18Rd.PDF
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace