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学科主题物理化学
Gd-Al co-doped mesoporous silica nanoparticles loaded with Ru(bpy)(3)(2+) as a dual-modality probe for fluorescence and magnetic resonance imaging
Zhang, Dan1,2; Gao, Ai1,2; Xu, Yang1,2; Yin, Xue-Bo1,2; He, Xi-Wen1,2; Zhang, Yu-Kui1,2,3; XueboYin
刊名ANALYST
2014-09-21
DOI10.1039/c4an00816b
139期:18页:4613-4619
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]CONTRAST AGENTS ; SUSPENSIONS ; PARTICLES ; TOXICITY ; MICE
英文摘要Mesoporous silica nanoparticles (MSNs) were co-doped with Gd3+ and Al3+ and then loaded with Ru(bpy)(3)(2+) by ion-exchange to prepare Ru/Gd-Al@MSNs. The as-prepared Ru/Gd-Al@MSNs were applied as contrast agents for in vivo fluorescence and magnetic resonance (MR) dual-modality imaging with a mouse as a model. The effects of Al3+ and MSNs on longitudinal relaxivity (r(1)) and fluorescence were investigated using a series of Gd-containing silica nanoparticles, including Gd@MSNs, Gd-Al@MSNs, and Ru/Gd-Al@nonporous silica nanoparticles. Co-doping with Al3+ improved the loading of Gd3+; the mesoporous structure improved the water exchange rate. The improvement enhanced the MR imaging efficiency of the Ru/Gd-Al@MSN probe. A higher relaxivity (19.2 mM(-1) s(-1)) was observed compared to that from a commercial contrast agent, Gd-diethylene triamine pentaacetic acid (GdDTPA). Importantly, the mesoporous structure provided a large specific surface area for the loading of Ru(bpy)(3)(2+) by a simple ion-exchange procedure. Intense red fluorescence was observed from Ru/Gd-Al@MSN probes. The versatility of Ru/Gd-Al@MSNs for dual-modality imaging was demonstrated using in vivo fluorescence imaging and T-1-weighted MR imaging with a mouse model. The nanoparticles are biocompatible and may be attractive for clinical applications.
语种英语
WOS记录号WOS:000340755000028
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/144452
专题中国科学院大连化学物理研究所
通讯作者XueboYin
作者单位1.Nankai Univ, Coll Chem, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Nankai Univ, Coll Chem, Res Ctr Analyt Sci, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Nat Chromatog R&A Ctr, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
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GB/T 7714
Zhang, Dan,Gao, Ai,Xu, Yang,et al. Gd-Al co-doped mesoporous silica nanoparticles loaded with Ru(bpy)(3)(2+) as a dual-modality probe for fluorescence and magnetic resonance imaging[J]. ANALYST,2014,139(18):4613-4619.
APA Zhang, Dan.,Gao, Ai.,Xu, Yang.,Yin, Xue-Bo.,He, Xi-Wen.,...&XueboYin.(2014).Gd-Al co-doped mesoporous silica nanoparticles loaded with Ru(bpy)(3)(2+) as a dual-modality probe for fluorescence and magnetic resonance imaging.ANALYST,139(18),4613-4619.
MLA Zhang, Dan,et al."Gd-Al co-doped mesoporous silica nanoparticles loaded with Ru(bpy)(3)(2+) as a dual-modality probe for fluorescence and magnetic resonance imaging".ANALYST 139.18(2014):4613-4619.
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