DICP OpenIR
Subject Area物理化学
Gd-Al co-doped mesoporous silica nanoparticles loaded with Ru(bpy)(3)(2+) as a dual-modality probe for fluorescence and magnetic resonance imaging
Zhang, Dan1,2; Gao, Ai1,2; Xu, Yang1,2; Yin, Xue-Bo1,2; He, Xi-Wen1,2; Zhang, Yu-Kui1,2,3; XueboYin
Source PublicationANALYST
2014-09-21
DOI10.1039/c4an00816b
Volume139Issue:18Pages:4613-4619
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordCONTRAST AGENTS ; SUSPENSIONS ; PARTICLES ; TOXICITY ; MICE
AbstractMesoporous silica nanoparticles (MSNs) were co-doped with Gd3+ and Al3+ and then loaded with Ru(bpy)(3)(2+) by ion-exchange to prepare Ru/Gd-Al@MSNs. The as-prepared Ru/Gd-Al@MSNs were applied as contrast agents for in vivo fluorescence and magnetic resonance (MR) dual-modality imaging with a mouse as a model. The effects of Al3+ and MSNs on longitudinal relaxivity (r(1)) and fluorescence were investigated using a series of Gd-containing silica nanoparticles, including Gd@MSNs, Gd-Al@MSNs, and Ru/Gd-Al@nonporous silica nanoparticles. Co-doping with Al3+ improved the loading of Gd3+; the mesoporous structure improved the water exchange rate. The improvement enhanced the MR imaging efficiency of the Ru/Gd-Al@MSN probe. A higher relaxivity (19.2 mM(-1) s(-1)) was observed compared to that from a commercial contrast agent, Gd-diethylene triamine pentaacetic acid (GdDTPA). Importantly, the mesoporous structure provided a large specific surface area for the loading of Ru(bpy)(3)(2+) by a simple ion-exchange procedure. Intense red fluorescence was observed from Ru/Gd-Al@MSN probes. The versatility of Ru/Gd-Al@MSNs for dual-modality imaging was demonstrated using in vivo fluorescence imaging and T-1-weighted MR imaging with a mouse model. The nanoparticles are biocompatible and may be attractive for clinical applications.
Language英语
WOS IDWOS:000340755000028
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/144452
Collection中国科学院大连化学物理研究所
Corresponding AuthorXueboYin
Affiliation1.Nankai Univ, Coll Chem, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Nankai Univ, Coll Chem, Res Ctr Analyt Sci, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Nat Chromatog R&A Ctr, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Dan,Gao, Ai,Xu, Yang,et al. Gd-Al co-doped mesoporous silica nanoparticles loaded with Ru(bpy)(3)(2+) as a dual-modality probe for fluorescence and magnetic resonance imaging[J]. ANALYST,2014,139(18):4613-4619.
APA Zhang, Dan.,Gao, Ai.,Xu, Yang.,Yin, Xue-Bo.,He, Xi-Wen.,...&XueboYin.(2014).Gd-Al co-doped mesoporous silica nanoparticles loaded with Ru(bpy)(3)(2+) as a dual-modality probe for fluorescence and magnetic resonance imaging.ANALYST,139(18),4613-4619.
MLA Zhang, Dan,et al."Gd-Al co-doped mesoporous silica nanoparticles loaded with Ru(bpy)(3)(2+) as a dual-modality probe for fluorescence and magnetic resonance imaging".ANALYST 139.18(2014):4613-4619.
Files in This Item:
File Name/Size DocType Version Access License
2014ePrG5Y18Rd.PDF(1346KB)期刊论文作者接受稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Dan]'s Articles
[Gao, Ai]'s Articles
[Xu, Yang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Dan]'s Articles
[Gao, Ai]'s Articles
[Xu, Yang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Dan]'s Articles
[Gao, Ai]'s Articles
[Xu, Yang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.