DICP OpenIR
Subject Area物理化学
Monodisperse Boronate Polymeric Particles Synthesized by a Precipitation Polymerization Strategy: Particle Formation and Glycoprotein Response from the Standpoint of the Flory-Huggins Model
Liu, Jianxi1,2; Qu, Yanyan1,2; Yang, Kaiguang1; Wu, Qi1,2; Shan, Yichu1; Zhang, Lihua1; Liang, Zhen1; Zhang, Yukui1; Zhang LH(张丽华)
KeywordOne Pot Polymerization Glycoprotein Response Boronate Affinity Flory-huggins Model
Source PublicationACS APPLIED MATERIALS & INTERFACES
2014-02-12
DOI10.1021/am405144x
Volume6Issue:3Pages:2059-2066
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS KeywordBLOCK-COPOLYMERS ; PHYSIOLOGICAL PH ; ACID ; MICROSPHERES ; NANOPARTICLES ; ENRICHMENT ; RELEASE ; GLYCOPEPTIDES ; COMPOSITES ; MICROGELS
AbstractThe development of a highly specific recognition system for glycoprotein capture from complex biological samples is a prerequisite to the success of mass spectra-based glycoproteomics analysis. To achieve this purpose, a one-pot precipitation polymerization (PP) strategy with a novel solvent system composed of water/ethanol (4:1, v/v) is described for preparing boronate-affinity polymeric micro/nano particles using 4-vinylphenylboronic acid (VPBA) as the functional monomer and N,N'-methylenebis(acrylamide) (MBA) alone or together with divinylbenzene (DVB) as the cross-linker(s). The proposed polymerization strategy not only affords monodisperse polymeric submicrometer particles with a smooth surface and controllable size, ranging from 300 to 700 nm, but also increases the loading capacity of boronic acid, which could hardly be achieved by other polymerization methods, thus leading to the specific recognition of glycoproteins. The effects of solvent systems and monomers on the morphology and boronate-affinity capacity of prepared materials were further investigated based on the Flory-Huggins model. It was proved that the reaction rate of various monomers during particle formation might be the key factor affecting the affinity capacity for glycoproteins. Our results demonstrated that under the theoretical guidance of the Flory-Huggins model the PP strategy with a selected monomer and solvent system might provide a good approach to prepare submicrometer polymer particles with plenty of boronic acid groups on the surface to achieve a highly selective enrichment of glycoproteins.
Language英语
WOS IDWOS:000331493200096
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/144460
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhang LH(张丽华)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jianxi,Qu, Yanyan,Yang, Kaiguang,et al. Monodisperse Boronate Polymeric Particles Synthesized by a Precipitation Polymerization Strategy: Particle Formation and Glycoprotein Response from the Standpoint of the Flory-Huggins Model[J]. ACS APPLIED MATERIALS & INTERFACES,2014,6(3):2059-2066.
APA Liu, Jianxi.,Qu, Yanyan.,Yang, Kaiguang.,Wu, Qi.,Shan, Yichu.,...&张丽华.(2014).Monodisperse Boronate Polymeric Particles Synthesized by a Precipitation Polymerization Strategy: Particle Formation and Glycoprotein Response from the Standpoint of the Flory-Huggins Model.ACS APPLIED MATERIALS & INTERFACES,6(3),2059-2066.
MLA Liu, Jianxi,et al."Monodisperse Boronate Polymeric Particles Synthesized by a Precipitation Polymerization Strategy: Particle Formation and Glycoprotein Response from the Standpoint of the Flory-Huggins Model".ACS APPLIED MATERIALS & INTERFACES 6.3(2014):2059-2066.
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