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学科主题: 物理化学
题名: Blood volatile compounds as biomarkers for colorectal cancer
作者: Wang, Changsong1;  Li, Peng1;  Lian, Ailing1;  Sun, Bo1;  Wang, Xiaoyang1;  Guo, Lei1;  Chi, Chunjie1;  Liu, Shanshan1;  Zhao, Wei1;  Luo, Suqi1;  Guo, Zhigang1;  Zhang, Yang1;  Ke, Chaofu2;  Ye, Guozhu3;  Xu, Guowang3;  Zhang, Fengmin4, 5;  Li, Enyou1
通讯作者: 李恩有
关键词: colorectal cancer ;  biomarkers ;  volatile organic compounds ;  solid-phase microextraction ;  cancer diagnosis
刊名: CANCER BIOLOGY & THERAPY
发表日期: 2014-02-01
DOI: 10.4161/cbt.26723
卷: 15, 期:2, 页:200-206
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Oncology
研究领域[WOS]: Oncology
英文摘要: Many recent studies have focused on the connection between the composition of specific volatile organic compounds (VOCs) in exhaled breath and various forms of cancer. However, the composition of exhaled breath is affected by many factors, such as lung disease, smoking, and diet. VOCs are released into the bloodstream before they are exhaled; therefore, the analysis of VOCs in blood will provide more accurate results than the analysis of VOCs in exhaled breath. Blood were collected from 16 colorectal cancer patients and 20 healthy controls, then solid phase microextraction-chromatography-mass spectrometry (SPME-GC-MS) was used to analysis the exhaled volatile organic compounds (VOCs). The statistical methods principal component analysis (PCA) and partial least-squares discriminant analysis (PLSDA) were performed to deal with the final dates. Three metabolic biomarkers were found at significantly lower levels in the group of CRC patients than in the normal control group (P < 0.01): phenyl methylcarbamate, ethylhexanol, and 6-t-butyl-2,2,9,9-tetramethyl-3,5-decadien-7-yne. In addition, significantly higher levels of 1,1,4,4-tetramethyl-2,5-dimethylene-cyclohexane were found in the group of CRC patients than in the normal control group (P < 0.05). Compared with healthy individuals, patients with colorectal adenocarcinoma exhibited a distinct blood metabolic profile with respect to VOCs. The analysis of blood VOCs appears to have potential clinical applications for CRC screening.
关键词[WOS]: ORGANIC-COMPOUNDS ;  LUNG-CANCER ;  MOLECULAR BIOMARKERS ;  LIPID-PEROXIDATION ;  GASTRIC-CANCER ;  BREATH ;  DISEASE ;  SPECTROMETRY ;  EXPRESSION ;  DIAGNOSIS
语种: 英语
WOS记录号: WOS:000331333200008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144474
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin, Peoples R China
2.Harbin Med Univ, Sch Publ Hlth, Dept Biostat, Harbin, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
4.Harbin Med Univ, Dept Microbiol, Heilongjiang Key Lab Immun & Infect, Harbin, Peoples R China
5.Harbin Med Univ, Minist Educ, Key Lab Biopharmaceut, Harbin, Peoples R China

Recommended Citation:
Wang, Changsong,Li, Peng,Lian, Ailing,et al. Blood volatile compounds as biomarkers for colorectal cancer[J]. CANCER BIOLOGY & THERAPY,2014,15(2):200-206.
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