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学科主题: 物理化学
题名: The lipid profile of brown adipose tissue is sex-specific in mice
作者: Hoene, Miriam1;  Li, Jia4;  Haering, Hans-Ulrich1, 2, 3;  Weigert, Cora1, 2, 3;  Xu, Guowang4;  Lehmann, Rainer1, 2, 3
通讯作者: 许国旺 ;  RainerLehmann
关键词: Brown adipose tissue ;  White adipose tissue ;  Gonadal fat ;  Subcutaneous fat ;  Female and male mice ;  Tandem-MS lipidomics
刊名: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
发表日期: 2014-10-01
DOI: 10.1016/j.bbalip.2014.08.003
卷: 1841, 期:10, 页:1563-1570
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Biophysics ;  Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biophysics ;  Cell Biology
英文摘要: Brown adipose tissue (BAT) is a thermogenic organ with a vital function in small mammals and potential as metabolic drug target in humans. By using high-resolution LC-tandem-mass spectrometry, we quantified 329 lipid species from 17 (sub)classes and identified the fatty acid composition of all phospholipids from BAT and subcutaneous and gonadal white adipose tissue (WAT) from female and male mice. Phospholipids and free fatty acids were higher in BAT, while DAG and TAG levels were higher in WAT. A set of phospholipids dominated by the residue docosahexaenoic acid, which influences membrane fluidity, showed the highest specificity for BAT. We additionally detected major sex-specific differences between the BAT lipid profiles, while samples from the different WAT depots were comparatively similar. Female BAT contained less triacylglycerol and more phospholipids rich in arachidonic and stearic acid whereas another set of fatty acid residues that included linoleic and palmitic acid prevailed in males. These differences in phospholipid fatty acid composition could greatly affect mitochondrial membranes and other cellular organelles and thereby regulate the function of BAT in a sex-specific manner. (C) 2014 The Authors. Published by Elsevier B.V.
关键词[WOS]: FATTY-ACID-COMPOSITION ;  DOCOSAHEXAENOIC ACID ;  INSULIN SENSITIVITY ;  COLD-ACCLIMATION ;  MITOCHONDRIAL BIOGENESIS ;  EICOSAPENTAENOIC ACID ;  DEPENDENT DIFFERENCES ;  UNCOUPLING PROTEIN ;  ADULT HUMANS ;  RATS
语种: 英语
WOS记录号: WOS:000342864900025
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144475
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Tubingen Hosp, Dept Internal Med 4, Div Clin Chem & Pathobiochem, Tubingen, Germany
2.Univ Tubingen, Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis, Tubingen, Germany
3.German Ctr Diabet Res DZD, Tubingen, Germany
4.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

Recommended Citation:
Hoene, Miriam,Li, Jia,Haering, Hans-Ulrich,et al. The lipid profile of brown adipose tissue is sex-specific in mice[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,2014,1841(10):1563-1570.
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