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学科主题物理化学
The lipid profile of brown adipose tissue is sex-specific in mice
Hoene, Miriam1; Li, Jia4; Haering, Hans-Ulrich1,2,3; Weigert, Cora1,2,3; Xu, Guowang4; Lehmann, Rainer1,2,3; Xu GW(许国旺); RainerLehmann
关键词Brown Adipose Tissue White Adipose Tissue Gonadal Fat Subcutaneous Fat FeMale And Male Mice Tandem-ms Lipidomics
刊名BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
2014-10-01
DOI10.1016/j.bbalip.2014.08.003
1841期:10页:1563-1570
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]FATTY-ACID-COMPOSITION ; DOCOSAHEXAENOIC ACID ; INSULIN SENSITIVITY ; COLD-ACCLIMATION ; MITOCHONDRIAL BIOGENESIS ; EICOSAPENTAENOIC ACID ; DEPENDENT DIFFERENCES ; UNCOUPLING PROTEIN ; ADULT HUMANS ; RATS
英文摘要Brown adipose tissue (BAT) is a thermogenic organ with a vital function in small mammals and potential as metabolic drug target in humans. By using high-resolution LC-tandem-mass spectrometry, we quantified 329 lipid species from 17 (sub)classes and identified the fatty acid composition of all phospholipids from BAT and subcutaneous and gonadal white adipose tissue (WAT) from female and male mice. Phospholipids and free fatty acids were higher in BAT, while DAG and TAG levels were higher in WAT. A set of phospholipids dominated by the residue docosahexaenoic acid, which influences membrane fluidity, showed the highest specificity for BAT. We additionally detected major sex-specific differences between the BAT lipid profiles, while samples from the different WAT depots were comparatively similar. Female BAT contained less triacylglycerol and more phospholipids rich in arachidonic and stearic acid whereas another set of fatty acid residues that included linoleic and palmitic acid prevailed in males. These differences in phospholipid fatty acid composition could greatly affect mitochondrial membranes and other cellular organelles and thereby regulate the function of BAT in a sex-specific manner. (C) 2014 The Authors. Published by Elsevier B.V.
语种英语
WOS记录号WOS:000342864900025
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/144475
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺); RainerLehmann
作者单位1.Univ Tubingen Hosp, Dept Internal Med 4, Div Clin Chem & Pathobiochem, Tubingen, Germany
2.Univ Tubingen, Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis, Tubingen, Germany
3.German Ctr Diabet Res DZD, Tubingen, Germany
4.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
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GB/T 7714
Hoene, Miriam,Li, Jia,Haering, Hans-Ulrich,et al. The lipid profile of brown adipose tissue is sex-specific in mice[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,2014,1841(10):1563-1570.
APA Hoene, Miriam.,Li, Jia.,Haering, Hans-Ulrich.,Weigert, Cora.,Xu, Guowang.,...&RainerLehmann.(2014).The lipid profile of brown adipose tissue is sex-specific in mice.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,1841(10),1563-1570.
MLA Hoene, Miriam,et al."The lipid profile of brown adipose tissue is sex-specific in mice".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1841.10(2014):1563-1570.
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