DICP OpenIR
Subject Area物理化学
The lipid profile of brown adipose tissue is sex-specific in mice
Hoene, Miriam1; Li, Jia4; Haering, Hans-Ulrich1,2,3; Weigert, Cora1,2,3; Xu, Guowang4; Lehmann, Rainer1,2,3; Xu GW(许国旺); RainerLehmann
KeywordBrown Adipose Tissue White Adipose Tissue Gonadal Fat Subcutaneous Fat FeMale And Male Mice Tandem-ms Lipidomics
Source PublicationBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
2014-10-01
DOI10.1016/j.bbalip.2014.08.003
Volume1841Issue:10Pages:1563-1570
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS KeywordFATTY-ACID-COMPOSITION ; DOCOSAHEXAENOIC ACID ; INSULIN SENSITIVITY ; COLD-ACCLIMATION ; MITOCHONDRIAL BIOGENESIS ; EICOSAPENTAENOIC ACID ; DEPENDENT DIFFERENCES ; UNCOUPLING PROTEIN ; ADULT HUMANS ; RATS
AbstractBrown adipose tissue (BAT) is a thermogenic organ with a vital function in small mammals and potential as metabolic drug target in humans. By using high-resolution LC-tandem-mass spectrometry, we quantified 329 lipid species from 17 (sub)classes and identified the fatty acid composition of all phospholipids from BAT and subcutaneous and gonadal white adipose tissue (WAT) from female and male mice. Phospholipids and free fatty acids were higher in BAT, while DAG and TAG levels were higher in WAT. A set of phospholipids dominated by the residue docosahexaenoic acid, which influences membrane fluidity, showed the highest specificity for BAT. We additionally detected major sex-specific differences between the BAT lipid profiles, while samples from the different WAT depots were comparatively similar. Female BAT contained less triacylglycerol and more phospholipids rich in arachidonic and stearic acid whereas another set of fatty acid residues that included linoleic and palmitic acid prevailed in males. These differences in phospholipid fatty acid composition could greatly affect mitochondrial membranes and other cellular organelles and thereby regulate the function of BAT in a sex-specific manner. (C) 2014 The Authors. Published by Elsevier B.V.
Language英语
WOS IDWOS:000342864900025
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/144475
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu GW(许国旺); RainerLehmann
Affiliation1.Univ Tubingen Hosp, Dept Internal Med 4, Div Clin Chem & Pathobiochem, Tubingen, Germany
2.Univ Tubingen, Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis, Tubingen, Germany
3.German Ctr Diabet Res DZD, Tubingen, Germany
4.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Hoene, Miriam,Li, Jia,Haering, Hans-Ulrich,et al. The lipid profile of brown adipose tissue is sex-specific in mice[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,2014,1841(10):1563-1570.
APA Hoene, Miriam.,Li, Jia.,Haering, Hans-Ulrich.,Weigert, Cora.,Xu, Guowang.,...&RainerLehmann.(2014).The lipid profile of brown adipose tissue is sex-specific in mice.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,1841(10),1563-1570.
MLA Hoene, Miriam,et al."The lipid profile of brown adipose tissue is sex-specific in mice".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1841.10(2014):1563-1570.
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