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学科主题: 物理化学
题名: Study of urinary steroid hormone disorders: difference between hepatocellular carcinoma in early stage and cirrhosis
作者: Dai, Weidong1;  Yin, Peiyuan1;  Chen, Ping2;  Kong, Hongwei1;  Luo, Ping1;  Xu, Zhiliang1;  Lu, Xin1;  Xu, Guowang1
通讯作者: 许国旺
关键词: Steroid hormone ;  LC-MS ;  Hepatocellular carcinoma ;  Liver cirrhosis ;  Biomarker ;  Metabolomics
刊名: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
发表日期: 2014-07-01
DOI: 10.1007/s00216-014-7843-3
卷: 406, 期:18, 页:4325-4335
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. Discovery of novel biomarkers for early HCC from other liver diseases such as cirrhosis is of great clinical benefit. In this study, a novel steroid hormone metabolomic method based on liquid chromatography-mass spectrometry combined with logistic regression analysis was applied to study the steroid hormone disorders and to screen potential urinary steroid hormone biomarkers of early HCC. Thirty-six urinary steroid hormones were detected and quantified in healthy controls, cirrhotic patients, and early HCC patients. Heat map analysis and multivariate statistical analysis suggested severe disorders of steroid hormone network and holistically decreased urinary steroid hormone pattern in cirrhotic and early HCC patients. Logistic regression analysis reveals that a panel of two urinary steroid hormones (epitestosterone and allotetrahydrocortisol) displayed excellent diagnostic capability for distinguishing early HCC from cirrhosis with area under the curve (AUC) = 0.938 of receiver operating characteristic (ROC) analysis. These results help to overcome the disadvantage of lower sensitivity and specificity of alpha-fetoprotein for distinguishing early HCC from cirrhosis. Our work shows that steroid hormone metabolomics is a promising biomarker tool for biomarker study of early HCC.
关键词[WOS]: CHROMATOGRAPHY-MASS-SPECTROMETRY ;  LIVER-CIRRHOSIS ;  CANCER ;  RISK ;  TESTOSTERONE ;  METABOLOMICS ;  TAMOXIFEN ;  TRIAL
语种: 英语
WOS记录号: WOS:000338722400002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144484
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Zhejiang Chinese Med Univ, Affiliated Hosp 1, Hangzhou 310006, Zhejiang, Peoples R China

Recommended Citation:
Dai, Weidong,Yin, Peiyuan,Chen, Ping,et al. Study of urinary steroid hormone disorders: difference between hepatocellular carcinoma in early stage and cirrhosis[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2014,406(18):4325-4335.
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