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学科主题: 物理化学
题名: Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry
作者: Zhou, Lina1;  Liao, Yuan2;  Yin, Peiyuan1;  Zeng, Zhongda1;  Li, Jia1;  Lu, Xin1;  Zheng, Limin2;  Xu, Guowang1
通讯作者: 许国旺
关键词: Metabolic profiling ;  Hepatocellular carcinoma ;  Curative resection ;  Early recurrence ;  Metabolomics
刊名: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
发表日期: 2014-09-01
DOI: 10.1016/j.jchromb.2014.01.057
卷: 966, 期:1, 页:163-170
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: The objectives of this pilot study were to predict early postoperative recurrence in hepatocellular carcinoma (HCC) patients based on metabolic features and to explore the related metabolic disturbances. Liquid chromatography-mass spectrometry-based metabolic profiling was performed on the plasma of 18 late recurrent and 22 early recurrent HCC patients. Metabolic differences were found to be related to amino acid, bile acid, cholesterol, fatty acid, phospholipid and carbohydrate metabolism. Bile acids, steroids and fatty acids showed significant variation in the early recurrent HCC group compared to the late recurrence group. Decreased levels of polyunsaturated eicosapentaenoic acid, docosahexaenoic acid and linolenic acid were found to be specific metabolic features for early recurrence. With the combination of methionine, GCDCA and cholesterol sulfate, 85% of the early recurrent HCCs can be predicted correctly with the corresponding area under the curve (AUC) equal to 0.95 in the training set, and 80% of the early recurrent HCCs can be predicted correctly with the corresponding AUC equal to 0.91 in the test set. (C) 2014 Elsevier B.V. All rights reserved.
关键词[WOS]: LATE INTRAHEPATIC RECURRENCE ;  RISK-FACTORS ;  CURATIVE RESECTION ;  LIVER-CIRRHOSIS ;  PREDICTION ;  BIOMARKERS ;  HEPATECTOMY ;  INVASION ;  OUTCOMES ;  SINGLE
语种: 英语
WOS记录号: WOS:000340323200020
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144487
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Sun Yat Sen Zhongshan Univ, State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Zhou, Lina,Liao, Yuan,Yin, Peiyuan,et al. Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2014,966(1):163-170.
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