DICP OpenIR
Subject Area物理化学
Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry
Zhou, Lina1; Liao, Yuan2; Yin, Peiyuan1; Zeng, Zhongda1; Li, Jia1; Lu, Xin1; Zheng, Limin2; Xu, Guowang1; Xu GW(许国旺)
KeywordMetabolic Profiling Hepatocellular Carcinoma Curative Resection Early Recurrence Metabolomics
Source PublicationJOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2014-09-01
DOI10.1016/j.jchromb.2014.01.057
Volume966Issue:1Pages:163-170
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordLATE INTRAHEPATIC RECURRENCE ; RISK-FACTORS ; CURATIVE RESECTION ; LIVER-CIRRHOSIS ; PREDICTION ; BIOMARKERS ; HEPATECTOMY ; INVASION ; OUTCOMES ; SINGLE
AbstractThe objectives of this pilot study were to predict early postoperative recurrence in hepatocellular carcinoma (HCC) patients based on metabolic features and to explore the related metabolic disturbances. Liquid chromatography-mass spectrometry-based metabolic profiling was performed on the plasma of 18 late recurrent and 22 early recurrent HCC patients. Metabolic differences were found to be related to amino acid, bile acid, cholesterol, fatty acid, phospholipid and carbohydrate metabolism. Bile acids, steroids and fatty acids showed significant variation in the early recurrent HCC group compared to the late recurrence group. Decreased levels of polyunsaturated eicosapentaenoic acid, docosahexaenoic acid and linolenic acid were found to be specific metabolic features for early recurrence. With the combination of methionine, GCDCA and cholesterol sulfate, 85% of the early recurrent HCCs can be predicted correctly with the corresponding area under the curve (AUC) equal to 0.95 in the training set, and 80% of the early recurrent HCCs can be predicted correctly with the corresponding AUC equal to 0.91 in the test set. (C) 2014 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000340323200020
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/144487
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu GW(许国旺)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Sun Yat Sen Zhongshan Univ, State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Lina,Liao, Yuan,Yin, Peiyuan,et al. Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2014,966(1):163-170.
APA Zhou, Lina.,Liao, Yuan.,Yin, Peiyuan.,Zeng, Zhongda.,Li, Jia.,...&许国旺.(2014).Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,966(1),163-170.
MLA Zhou, Lina,et al."Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 966.1(2014):163-170.
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