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学科主题物理化学
Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry
Zhou, Lina1; Liao, Yuan2; Yin, Peiyuan1; Zeng, Zhongda1; Li, Jia1; Lu, Xin1; Zheng, Limin2; Xu, Guowang1; Xu GW(许国旺)
关键词Metabolic Profiling Hepatocellular Carcinoma Curative Resection Early Recurrence Metabolomics
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2014-09-01
DOI10.1016/j.jchromb.2014.01.057
966期:1页:163-170
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]LATE INTRAHEPATIC RECURRENCE ; RISK-FACTORS ; CURATIVE RESECTION ; LIVER-CIRRHOSIS ; PREDICTION ; BIOMARKERS ; HEPATECTOMY ; INVASION ; OUTCOMES ; SINGLE
英文摘要The objectives of this pilot study were to predict early postoperative recurrence in hepatocellular carcinoma (HCC) patients based on metabolic features and to explore the related metabolic disturbances. Liquid chromatography-mass spectrometry-based metabolic profiling was performed on the plasma of 18 late recurrent and 22 early recurrent HCC patients. Metabolic differences were found to be related to amino acid, bile acid, cholesterol, fatty acid, phospholipid and carbohydrate metabolism. Bile acids, steroids and fatty acids showed significant variation in the early recurrent HCC group compared to the late recurrence group. Decreased levels of polyunsaturated eicosapentaenoic acid, docosahexaenoic acid and linolenic acid were found to be specific metabolic features for early recurrence. With the combination of methionine, GCDCA and cholesterol sulfate, 85% of the early recurrent HCCs can be predicted correctly with the corresponding area under the curve (AUC) equal to 0.95 in the training set, and 80% of the early recurrent HCCs can be predicted correctly with the corresponding AUC equal to 0.91 in the test set. (C) 2014 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000340323200020
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/144487
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Sun Yat Sen Zhongshan Univ, State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China
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Zhou, Lina,Liao, Yuan,Yin, Peiyuan,et al. Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2014,966(1):163-170.
APA Zhou, Lina.,Liao, Yuan.,Yin, Peiyuan.,Zeng, Zhongda.,Li, Jia.,...&许国旺.(2014).Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,966(1),163-170.
MLA Zhou, Lina,et al."Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 966.1(2014):163-170.
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