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学科主题: 物理化学
题名: A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography
作者: Qiao, Lizhen1;  Wang, Shuangyuan1;  Li, Hua1;  Shan, Yuanhong1;  Dou, Abo1;  Shi, Xianzhe1;  Xu, Guowang1
通讯作者: 石先哲 ;  许国旺
关键词: Glucaminium-based ionic liquid ;  Hydrophilic interaction chromatography ;  Anion-exchange ;  Stationary phase
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2014-09-19
DOI: 10.1016/j.chroma.2014.07.096
卷: 1360, 期:1, 页:240-247
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Glucaminium-based ionic liquids are a new class of recently developed ionic liquids and prepared by functionalizing the amine group of N-methyl-D-glucamine, which renders them good hydrophilicity due to the presence of the glucose structure and charged quaternary ammonium group. In the present study, a glucaminium-based ionic liquid N,N-diallyl-N-methyl-D-glucaminium bromide was synthesized and subsequently bonded to the surface of 3-mercaptopropyl modified silica materials through "thiol-ene" click chemistry. The obtained stationary phase was characterized by elemental analysis and infrared spectroscopy, and then packed as a HPLC column. A mixture of five nucleosides was used to characterize the separation performance of the obtained column under HILIC mode and the column efficiency was determined with cytidine as the test solute, reaching 80,000 plates/m. Then, the retention behavior was evaluated by investigating the effect of various chromatographic factors on retention of different types of solutes, and the results revealed that the developed surface-confined glucaminium-based ionic liquid stationary phase exhibited a hydrophilic interaction/anion-exchange mixed-mode retention mechanism. Finally, two mixtures of nucleotides and flavonoids were separated on the glucaminium-based ionic liquid column, respectively under hydrophilic interaction and hydrophilic interaction/anion-exchange mixed-mode chromatography. In conclusion, the multimodal retention capabilities of the glucaminium-based ionic liquid column could offer a wider range of retention behavior and flexible selectivity toward polar and hydrophilic compounds. (C) 2014 Elsevier B.V. All rights reserved.
关键词[WOS]: SOLVATION ENERGY RELATIONSHIPS ;  REVERSED-PHASE ;  PHENOLIC-ACIDS ;  SEPARATION ;  PERFORMANCE ;  RETENTION ;  SELECTIVITY ;  EXTRACTION ;  FLAVONOIDS ;  CHEMISTRY
语种: 英语
WOS记录号: WOS:000341469400025
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144488
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

Recommended Citation:
Qiao, Lizhen,Wang, Shuangyuan,Li, Hua,et al. A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2014,1360(1):240-247.
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