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学科主题物理化学
A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography
Qiao, Lizhen; Wang, Shuangyuan; Li, Hua; Shan, Yuanhong; Dou, Abo; Shi, Xianzhe; Xu, Guowang; Shi XZ(石先哲); Xu GW(许国旺)
关键词Glucaminium-based Ionic Liquid Hydrophilic Interaction Chromatography Anion-exchange Stationary Phase
刊名JOURNAL OF CHROMATOGRAPHY A
2014-09-19
DOI10.1016/j.chroma.2014.07.096
1360期:1页:240-247
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]SOLVATION ENERGY RELATIONSHIPS ; REVERSED-PHASE ; PHENOLIC-ACIDS ; SEPARATION ; PERFORMANCE ; RETENTION ; SELECTIVITY ; EXTRACTION ; FLAVONOIDS ; CHEMISTRY
英文摘要Glucaminium-based ionic liquids are a new class of recently developed ionic liquids and prepared by functionalizing the amine group of N-methyl-D-glucamine, which renders them good hydrophilicity due to the presence of the glucose structure and charged quaternary ammonium group. In the present study, a glucaminium-based ionic liquid N,N-diallyl-N-methyl-D-glucaminium bromide was synthesized and subsequently bonded to the surface of 3-mercaptopropyl modified silica materials through "thiol-ene" click chemistry. The obtained stationary phase was characterized by elemental analysis and infrared spectroscopy, and then packed as a HPLC column. A mixture of five nucleosides was used to characterize the separation performance of the obtained column under HILIC mode and the column efficiency was determined with cytidine as the test solute, reaching 80,000 plates/m. Then, the retention behavior was evaluated by investigating the effect of various chromatographic factors on retention of different types of solutes, and the results revealed that the developed surface-confined glucaminium-based ionic liquid stationary phase exhibited a hydrophilic interaction/anion-exchange mixed-mode retention mechanism. Finally, two mixtures of nucleotides and flavonoids were separated on the glucaminium-based ionic liquid column, respectively under hydrophilic interaction and hydrophilic interaction/anion-exchange mixed-mode chromatography. In conclusion, the multimodal retention capabilities of the glucaminium-based ionic liquid column could offer a wider range of retention behavior and flexible selectivity toward polar and hydrophilic compounds. (C) 2014 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000341469400025
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/144488
专题中国科学院大连化学物理研究所
通讯作者Shi XZ(石先哲); Xu GW(许国旺)
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Qiao, Lizhen,Wang, Shuangyuan,Li, Hua,et al. A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2014,1360(1):240-247.
APA Qiao, Lizhen.,Wang, Shuangyuan.,Li, Hua.,Shan, Yuanhong.,Dou, Abo.,...&许国旺.(2014).A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography.JOURNAL OF CHROMATOGRAPHY A,1360(1),240-247.
MLA Qiao, Lizhen,et al."A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography".JOURNAL OF CHROMATOGRAPHY A 1360.1(2014):240-247.
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