DICP OpenIR
Subject Area物理化学
A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography
Qiao, Lizhen; Wang, Shuangyuan; Li, Hua; Shan, Yuanhong; Dou, Abo; Shi, Xianzhe; Xu, Guowang; Shi XZ(石先哲); Xu GW(许国旺)
KeywordGlucaminium-based Ionic Liquid Hydrophilic Interaction Chromatography Anion-exchange Stationary Phase
Source PublicationJOURNAL OF CHROMATOGRAPHY A
2014-09-19
DOI10.1016/j.chroma.2014.07.096
Volume1360Issue:1Pages:240-247
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordSOLVATION ENERGY RELATIONSHIPS ; REVERSED-PHASE ; PHENOLIC-ACIDS ; SEPARATION ; PERFORMANCE ; RETENTION ; SELECTIVITY ; EXTRACTION ; FLAVONOIDS ; CHEMISTRY
AbstractGlucaminium-based ionic liquids are a new class of recently developed ionic liquids and prepared by functionalizing the amine group of N-methyl-D-glucamine, which renders them good hydrophilicity due to the presence of the glucose structure and charged quaternary ammonium group. In the present study, a glucaminium-based ionic liquid N,N-diallyl-N-methyl-D-glucaminium bromide was synthesized and subsequently bonded to the surface of 3-mercaptopropyl modified silica materials through "thiol-ene" click chemistry. The obtained stationary phase was characterized by elemental analysis and infrared spectroscopy, and then packed as a HPLC column. A mixture of five nucleosides was used to characterize the separation performance of the obtained column under HILIC mode and the column efficiency was determined with cytidine as the test solute, reaching 80,000 plates/m. Then, the retention behavior was evaluated by investigating the effect of various chromatographic factors on retention of different types of solutes, and the results revealed that the developed surface-confined glucaminium-based ionic liquid stationary phase exhibited a hydrophilic interaction/anion-exchange mixed-mode retention mechanism. Finally, two mixtures of nucleotides and flavonoids were separated on the glucaminium-based ionic liquid column, respectively under hydrophilic interaction and hydrophilic interaction/anion-exchange mixed-mode chromatography. In conclusion, the multimodal retention capabilities of the glucaminium-based ionic liquid column could offer a wider range of retention behavior and flexible selectivity toward polar and hydrophilic compounds. (C) 2014 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000341469400025
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/144488
Collection中国科学院大连化学物理研究所
Corresponding AuthorShi XZ(石先哲); Xu GW(许国旺)
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Qiao, Lizhen,Wang, Shuangyuan,Li, Hua,et al. A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2014,1360(1):240-247.
APA Qiao, Lizhen.,Wang, Shuangyuan.,Li, Hua.,Shan, Yuanhong.,Dou, Abo.,...&许国旺.(2014).A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography.JOURNAL OF CHROMATOGRAPHY A,1360(1),240-247.
MLA Qiao, Lizhen,et al."A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography".JOURNAL OF CHROMATOGRAPHY A 1360.1(2014):240-247.
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