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学科主题: 物理化学
题名: Noninvasive detection of colorectal cancer by analysis of exhaled breath
作者: Wang, Changsong1, 4, 5;  Ke, Chaofu2;  Wang, Xiaoyang1;  Chi, Chunjie1;  Guo, Lei1;  Luo, Suqi1;  Guo, Zhigang1;  Xu, Guowang3;  Zhang, Fengmin4, 5;  Li, Enyou1
通讯作者: 李恩有
关键词: Biomarkers ;  Cancer diagnosis ;  Colorectal cancer ;  Solid-phase microextraction ;  Volatile organic compounds
刊名: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
发表日期: 2014-07-01
DOI: 10.1007/s00216-014-7865-x
卷: 406, 期:19, 页:4757-4763
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: There has been growing interest in exhaled breath analysis for cancer screening and disease monitoring; however, limited breath biomarker information exists regarding colorectal cancer (CRC). The objective of this study was to screen for breath biomarkers of CRC. Exhaled breath was collected from 20 CRC patients and 20 healthy controls; subsequently, solid-phase microextraction-gas chromatography/mass spectrometry (SPME-GC/MS) was used to assess the exhaled volatile organic compounds (VOCs) of the study participants. The statistical methods of principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were performed to process the final data. The VOCs in the exhalations of CRC patients exhibited significant differences from the VOCs in the exhalations of healthy controls; in particular, relative to the latter exhalations, the former exhalations contain significantly higher levels of cyclohexanone, 2,2-dimethyldecane, dodecane, 4-ethyl-1-octyn-3-ol, ethylaniline, cyclooctylmethanol, trans-2-dodecen-1-ol, and 3-hydroxy-2,4,4-trimethylpentyl 2-methylpropanoate but significantly lower levels of 6-t-butyl-2,2,9,9-tetramethyl-3,5-decadien-7-yne (P < 0.05). Analyses of breath VOCs provide a related model of CRC exhalation that could represent an effective and convenient screening method for this disease.
关键词[WOS]: VOLATILE ORGANIC-COMPOUNDS ;  LUNG-CANCER ;  MOLECULAR BIOMARKERS ;  IN-VITRO ;  SPECTROMETRY ;  DIET
语种: 英语
WOS记录号: WOS:000339155500019
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144499
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Harbin Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Harbin 150001, Peoples R China
2.Harbin Med Univ, Sch Publ Hlth, Dept Biostat, Harbin 150081, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
4.Harbin Med Univ, Heilongjiang Key Lab Immun & Infect, Dept Microbiol, Harbin 150081, Peoples R China
5.Harbin Med Univ, Minist Educ, Key Lab Biopharmaceut, Harbin 150081, Peoples R China

Recommended Citation:
Wang, Changsong,Ke, Chaofu,Wang, Xiaoyang,et al. Noninvasive detection of colorectal cancer by analysis of exhaled breath[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2014,406(19):4757-4763.
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