DICP OpenIR
学科主题物理化学
Noninvasive detection of colorectal cancer by analysis of exhaled breath
Wang, Changsong1,4,5; Ke, Chaofu2; Wang, Xiaoyang1; Chi, Chunjie1; Guo, Lei1; Luo, Suqi1; Guo, Zhigang1; Xu, Guowang3; Zhang, Fengmin4,5; Li, Enyou1; Li EY(李恩有)
关键词Biomarkers Cancer Diagnosis Colorectal Cancer Solid-phase Microextraction Volatile Organic Compounds
刊名ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2014-07-01
DOI10.1007/s00216-014-7865-x
406期:19页:4757-4763
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]VOLATILE ORGANIC-COMPOUNDS ; LUNG-CANCER ; MOLECULAR BIOMARKERS ; IN-VITRO ; SPECTROMETRY ; DIET
英文摘要There has been growing interest in exhaled breath analysis for cancer screening and disease monitoring; however, limited breath biomarker information exists regarding colorectal cancer (CRC). The objective of this study was to screen for breath biomarkers of CRC. Exhaled breath was collected from 20 CRC patients and 20 healthy controls; subsequently, solid-phase microextraction-gas chromatography/mass spectrometry (SPME-GC/MS) was used to assess the exhaled volatile organic compounds (VOCs) of the study participants. The statistical methods of principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were performed to process the final data. The VOCs in the exhalations of CRC patients exhibited significant differences from the VOCs in the exhalations of healthy controls; in particular, relative to the latter exhalations, the former exhalations contain significantly higher levels of cyclohexanone, 2,2-dimethyldecane, dodecane, 4-ethyl-1-octyn-3-ol, ethylaniline, cyclooctylmethanol, trans-2-dodecen-1-ol, and 3-hydroxy-2,4,4-trimethylpentyl 2-methylpropanoate but significantly lower levels of 6-t-butyl-2,2,9,9-tetramethyl-3,5-decadien-7-yne (P < 0.05). Analyses of breath VOCs provide a related model of CRC exhalation that could represent an effective and convenient screening method for this disease.
语种英语
WOS记录号WOS:000339155500019
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/144499
专题中国科学院大连化学物理研究所
通讯作者Li EY(李恩有)
作者单位1.Harbin Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Harbin 150001, Peoples R China
2.Harbin Med Univ, Sch Publ Hlth, Dept Biostat, Harbin 150081, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
4.Harbin Med Univ, Heilongjiang Key Lab Immun & Infect, Dept Microbiol, Harbin 150081, Peoples R China
5.Harbin Med Univ, Minist Educ, Key Lab Biopharmaceut, Harbin 150081, Peoples R China
推荐引用方式
GB/T 7714
Wang, Changsong,Ke, Chaofu,Wang, Xiaoyang,et al. Noninvasive detection of colorectal cancer by analysis of exhaled breath[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2014,406(19):4757-4763.
APA Wang, Changsong.,Ke, Chaofu.,Wang, Xiaoyang.,Chi, Chunjie.,Guo, Lei.,...&李恩有.(2014).Noninvasive detection of colorectal cancer by analysis of exhaled breath.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,406(19),4757-4763.
MLA Wang, Changsong,et al."Noninvasive detection of colorectal cancer by analysis of exhaled breath".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 406.19(2014):4757-4763.
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