Subject Area物理化学
Noninvasive detection of colorectal cancer by analysis of exhaled breath
Wang, Changsong1,4,5; Ke, Chaofu2; Wang, Xiaoyang1; Chi, Chunjie1; Guo, Lei1; Luo, Suqi1; Guo, Zhigang1; Xu, Guowang3; Zhang, Fengmin4,5; Li, Enyou1; Li EY(李恩有)
KeywordBiomarkers Cancer Diagnosis Colorectal Cancer Solid-phase Microextraction Volatile Organic Compounds
Indexed BySCI
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
AbstractThere has been growing interest in exhaled breath analysis for cancer screening and disease monitoring; however, limited breath biomarker information exists regarding colorectal cancer (CRC). The objective of this study was to screen for breath biomarkers of CRC. Exhaled breath was collected from 20 CRC patients and 20 healthy controls; subsequently, solid-phase microextraction-gas chromatography/mass spectrometry (SPME-GC/MS) was used to assess the exhaled volatile organic compounds (VOCs) of the study participants. The statistical methods of principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were performed to process the final data. The VOCs in the exhalations of CRC patients exhibited significant differences from the VOCs in the exhalations of healthy controls; in particular, relative to the latter exhalations, the former exhalations contain significantly higher levels of cyclohexanone, 2,2-dimethyldecane, dodecane, 4-ethyl-1-octyn-3-ol, ethylaniline, cyclooctylmethanol, trans-2-dodecen-1-ol, and 3-hydroxy-2,4,4-trimethylpentyl 2-methylpropanoate but significantly lower levels of 6-t-butyl-2,2,9,9-tetramethyl-3,5-decadien-7-yne (P < 0.05). Analyses of breath VOCs provide a related model of CRC exhalation that could represent an effective and convenient screening method for this disease.
WOS IDWOS:000339155500019
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorLi EY(李恩有)
Affiliation1.Harbin Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Harbin 150001, Peoples R China
2.Harbin Med Univ, Sch Publ Hlth, Dept Biostat, Harbin 150081, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
4.Harbin Med Univ, Heilongjiang Key Lab Immun & Infect, Dept Microbiol, Harbin 150081, Peoples R China
5.Harbin Med Univ, Minist Educ, Key Lab Biopharmaceut, Harbin 150081, Peoples R China
Recommended Citation
GB/T 7714
Wang, Changsong,Ke, Chaofu,Wang, Xiaoyang,et al. Noninvasive detection of colorectal cancer by analysis of exhaled breath[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2014,406(19):4757-4763.
APA Wang, Changsong.,Ke, Chaofu.,Wang, Xiaoyang.,Chi, Chunjie.,Guo, Lei.,...&李恩有.(2014).Noninvasive detection of colorectal cancer by analysis of exhaled breath.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,406(19),4757-4763.
MLA Wang, Changsong,et al."Noninvasive detection of colorectal cancer by analysis of exhaled breath".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 406.19(2014):4757-4763.
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