DICP OpenIR
学科主题物理化学
Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging
Wu, Hao1,2; Zhao, Haidong3; Song, Xiaojie1,2; Li, Shen1,2; Ma, Xiaojun1; Tan, Mingqian1; Ma XJ(马小军); Tan MQ(谭明乾)
刊名JOURNAL OF MATERIALS CHEMISTRY B
2014-08-28
DOI10.1039/c4tb00761a
2期:32页:5302-5308
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Technology
类目[WOS]Materials Science, Biomaterials
研究领域[WOS]Materials Science
关键词[WOS]INDOCYANINE-GREEN ; SILICA NANOPARTICLES ; CONTRAST AGENT ; IN-VITRO ; CHITOSAN ; CANCER ; BIODISTRIBUTION ; MICELLES ; SURGERY ; SYSTEMS
英文摘要Fabrication of near-infrared (NIR) fluorescent nanoprobes (NPs) has drawn great attention due to their potential as highly sensitive optical probes for in vivo tumor molecular imaging. Herein, a facile strategy has been reported for the preparation of ultrasmall (<20 nm) indocyanine green (ICG)-containing NIR fluorescent NPs using self-assembly chemistry between folate (FA) modified water-soluble chitosan (WCS) and ICG. The ICG-containing NPs exhibit characteristics of crystalline solid, good photostability, low cytotoxicity and high tumor targeting ability for in vitro cell imaging. We also explored this system for in vivo tumor molecular imaging. Significant tumor accumulation was observed for both in vitro and in vivo tumor imaging in HeLa tumor cell imaging and xenograft-bearing mice model (2 mu mol kg(-1) at 48 and 72 h time points). The availability of these self-assembled NIR NPs provides a convenient tool for tumor imaging and detection.
语种英语
WOS记录号WOS:000340076100020
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/144519
专题中国科学院大连化学物理研究所
通讯作者Ma XJ(马小军); Tan MQ(谭明乾)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China
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Wu, Hao,Zhao, Haidong,Song, Xiaojie,et al. Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(32):5302-5308.
APA Wu, Hao.,Zhao, Haidong.,Song, Xiaojie.,Li, Shen.,Ma, Xiaojun.,...&谭明乾.(2014).Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging.JOURNAL OF MATERIALS CHEMISTRY B,2(32),5302-5308.
MLA Wu, Hao,et al."Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging".JOURNAL OF MATERIALS CHEMISTRY B 2.32(2014):5302-5308.
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