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学科主题: 物理化学
题名: Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging
作者: Wu, Hao1, 2;  Zhao, Haidong3;  Song, Xiaojie1, 2;  Li, Shen1, 2;  Ma, Xiaojun1;  Tan, Mingqian1
通讯作者: 马小军 ;  谭明乾
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2014-08-28
DOI: 10.1039/c4tb00761a
卷: 2, 期:32, 页:5302-5308
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Materials Science, Biomaterials
研究领域[WOS]: Materials Science
英文摘要: Fabrication of near-infrared (NIR) fluorescent nanoprobes (NPs) has drawn great attention due to their potential as highly sensitive optical probes for in vivo tumor molecular imaging. Herein, a facile strategy has been reported for the preparation of ultrasmall (<20 nm) indocyanine green (ICG)-containing NIR fluorescent NPs using self-assembly chemistry between folate (FA) modified water-soluble chitosan (WCS) and ICG. The ICG-containing NPs exhibit characteristics of crystalline solid, good photostability, low cytotoxicity and high tumor targeting ability for in vitro cell imaging. We also explored this system for in vivo tumor molecular imaging. Significant tumor accumulation was observed for both in vitro and in vivo tumor imaging in HeLa tumor cell imaging and xenograft-bearing mice model (2 mu mol kg(-1) at 48 and 72 h time points). The availability of these self-assembled NIR NPs provides a convenient tool for tumor imaging and detection.
关键词[WOS]: INDOCYANINE-GREEN ;  SILICA NANOPARTICLES ;  CONTRAST AGENT ;  IN-VITRO ;  CHITOSAN ;  CANCER ;  BIODISTRIBUTION ;  MICELLES ;  SURGERY ;  SYSTEMS
语种: 英语
WOS记录号: WOS:000340076100020
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144519
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China

Recommended Citation:
Wu, Hao,Zhao, Haidong,Song, Xiaojie,et al. Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(32):5302-5308.
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