DICP OpenIR
Subject Area物理化学
Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging
Wu, Hao1,2; Zhao, Haidong3; Song, Xiaojie1,2; Li, Shen1,2; Ma, Xiaojun1; Tan, Mingqian1; Ma XJ(马小军); Tan MQ(谭明乾)
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
2014-08-28
DOI10.1039/c4tb00761a
Volume2Issue:32Pages:5302-5308
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
WOS SubjectMaterials Science, Biomaterials
WOS Research AreaMaterials Science
WOS KeywordINDOCYANINE-GREEN ; SILICA NANOPARTICLES ; CONTRAST AGENT ; IN-VITRO ; CHITOSAN ; CANCER ; BIODISTRIBUTION ; MICELLES ; SURGERY ; SYSTEMS
AbstractFabrication of near-infrared (NIR) fluorescent nanoprobes (NPs) has drawn great attention due to their potential as highly sensitive optical probes for in vivo tumor molecular imaging. Herein, a facile strategy has been reported for the preparation of ultrasmall (<20 nm) indocyanine green (ICG)-containing NIR fluorescent NPs using self-assembly chemistry between folate (FA) modified water-soluble chitosan (WCS) and ICG. The ICG-containing NPs exhibit characteristics of crystalline solid, good photostability, low cytotoxicity and high tumor targeting ability for in vitro cell imaging. We also explored this system for in vivo tumor molecular imaging. Significant tumor accumulation was observed for both in vitro and in vivo tumor imaging in HeLa tumor cell imaging and xenograft-bearing mice model (2 mu mol kg(-1) at 48 and 72 h time points). The availability of these self-assembled NIR NPs provides a convenient tool for tumor imaging and detection.
Language英语
WOS IDWOS:000340076100020
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/144519
Collection中国科学院大连化学物理研究所
Corresponding AuthorMa XJ(马小军); Tan MQ(谭明乾)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Wu, Hao,Zhao, Haidong,Song, Xiaojie,et al. Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(32):5302-5308.
APA Wu, Hao.,Zhao, Haidong.,Song, Xiaojie.,Li, Shen.,Ma, Xiaojun.,...&谭明乾.(2014).Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging.JOURNAL OF MATERIALS CHEMISTRY B,2(32),5302-5308.
MLA Wu, Hao,et al."Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging".JOURNAL OF MATERIALS CHEMISTRY B 2.32(2014):5302-5308.
Files in This Item:
File Name/Size DocType Version Access License
2014u1u6YQMAqb.PDF(860KB)期刊论文作者接受稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wu, Hao]'s Articles
[Zhao, Haidong]'s Articles
[Song, Xiaojie]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wu, Hao]'s Articles
[Zhao, Haidong]'s Articles
[Song, Xiaojie]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wu, Hao]'s Articles
[Zhao, Haidong]'s Articles
[Song, Xiaojie]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.