DICP OpenIR
学科主题物理化学
Gastroretentive drug delivery systems for the treatment of Helicobacter pylori
Zhao, Shan1,2; Lv, Yan1,2; Zhang, Jian-Bin1,2; Wang, Bing1,2; Lv, Guo-Jun1; Ma, Xiao-Jun1; Ma XJ(马小军)
关键词Helicobacter Pylori Gastroretentive Systems Floating Systems Bioadhesive Systems Expandable Systems
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2014-07-28
DOI10.3748/wjg.v20.i28.9321
20期:28页:9321-9329
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]COMPRESSED COLLAGEN SPONGES ; IN-VITRO EVALUATION ; DOSAGE FORMS ; GASTRIC RETENTION ; MUCOADHESIVE MICROSPHERES ; SEQUENTIAL THERAPY ; NONDISINTEGRATING TABLETS ; ANTIBIOTIC-RESISTANCE ; SUPERPOROUS HYDROGELS ; INFECTION
英文摘要Helicobacter pylori (H. pylori) is one of the most common pathogenic bacterial infections and is found in the stomachs of approximately half of the world's population. It is the primary known cause of gastritis, gastroduodenal ulcer disease and gastric cancer. However, combined drug therapy as the general treatment in the clinic, the rise of antibiotic-resistant bacteria, adverse reactions and poor patient compliance are major obstacles to the eradication of H. pylori. Oral site-specific drug delivery systems that could increase the longevity of the treatment agent at the target site might improve the therapeutic effect and avoid side effects. Gastroretentive drug delivery systems potentially prolong the gastric retention time and controlled/sustained release of a drug, thereby increasing the concentration of the drug at the application site, potentially improving its bioavailability and reducing the necessary dosage. Recommended gastroretentive drug delivery systems for enhancing local drug delivery include floating systems, bioadhesive systems and expandable systems. In this review, we summarize the important physiological parameters of the gastrointestinal tract that affect the gastric residence time. We then focus on various aspects useful in the development of gastroretentive drug delivery systems, including current trends and the progress of novel forms, especially with respect to their application for the treatment of H. pylori infections. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
语种英语
WOS记录号WOS:000339389800013
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/144520
专题中国科学院大连化学物理研究所
通讯作者Ma XJ(马小军)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Liaoning Provin, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Shan,Lv, Yan,Zhang, Jian-Bin,et al. Gastroretentive drug delivery systems for the treatment of Helicobacter pylori[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2014,20(28):9321-9329.
APA Zhao, Shan.,Lv, Yan.,Zhang, Jian-Bin.,Wang, Bing.,Lv, Guo-Jun.,...&马小军.(2014).Gastroretentive drug delivery systems for the treatment of Helicobacter pylori.WORLD JOURNAL OF GASTROENTEROLOGY,20(28),9321-9329.
MLA Zhao, Shan,et al."Gastroretentive drug delivery systems for the treatment of Helicobacter pylori".WORLD JOURNAL OF GASTROENTEROLOGY 20.28(2014):9321-9329.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2014ZH7ILFzcxA.PDF(869KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, Shan]的文章
[Lv, Yan]的文章
[Zhang, Jian-Bin]的文章
百度学术
百度学术中相似的文章
[Zhao, Shan]的文章
[Lv, Yan]的文章
[Zhang, Jian-Bin]的文章
必应学术
必应学术中相似的文章
[Zhao, Shan]的文章
[Lv, Yan]的文章
[Zhang, Jian-Bin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。