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学科主题: 物理化学
题名: Gastroretentive drug delivery systems for the treatment of Helicobacter pylori
作者: Zhao, Shan1, 2;  Lv, Yan1, 2;  Zhang, Jian-Bin1, 2;  Wang, Bing1, 2;  Lv, Guo-Jun1;  Ma, Xiao-Jun1
通讯作者: 马小军
关键词: Helicobacter pylori ;  Gastroretentive systems ;  Floating systems ;  Bioadhesive systems ;  Expandable systems
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2014-07-28
DOI: 10.3748/wjg.v20.i28.9321
卷: 20, 期:28, 页:9321-9329
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
英文摘要: Helicobacter pylori (H. pylori) is one of the most common pathogenic bacterial infections and is found in the stomachs of approximately half of the world's population. It is the primary known cause of gastritis, gastroduodenal ulcer disease and gastric cancer. However, combined drug therapy as the general treatment in the clinic, the rise of antibiotic-resistant bacteria, adverse reactions and poor patient compliance are major obstacles to the eradication of H. pylori. Oral site-specific drug delivery systems that could increase the longevity of the treatment agent at the target site might improve the therapeutic effect and avoid side effects. Gastroretentive drug delivery systems potentially prolong the gastric retention time and controlled/sustained release of a drug, thereby increasing the concentration of the drug at the application site, potentially improving its bioavailability and reducing the necessary dosage. Recommended gastroretentive drug delivery systems for enhancing local drug delivery include floating systems, bioadhesive systems and expandable systems. In this review, we summarize the important physiological parameters of the gastrointestinal tract that affect the gastric residence time. We then focus on various aspects useful in the development of gastroretentive drug delivery systems, including current trends and the progress of novel forms, especially with respect to their application for the treatment of H. pylori infections. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
关键词[WOS]: COMPRESSED COLLAGEN SPONGES ;  IN-VITRO EVALUATION ;  DOSAGE FORMS ;  GASTRIC RETENTION ;  MUCOADHESIVE MICROSPHERES ;  SEQUENTIAL THERAPY ;  NONDISINTEGRATING TABLETS ;  ANTIBIOTIC-RESISTANCE ;  SUPERPOROUS HYDROGELS ;  INFECTION
语种: 英语
WOS记录号: WOS:000339389800013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144520
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Liaoning Provin, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Zhao, Shan,Lv, Yan,Zhang, Jian-Bin,et al. Gastroretentive drug delivery systems for the treatment of Helicobacter pylori[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2014,20(28):9321-9329.
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