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学科主题: 物理化学
题名: Natural Anionic Polymer Acts as Highly Efficient Trypsin Inhibitor Based on an Electrostatic Interaction Mechanism
作者: Lv, Yan1, 2;  Zhang, Jianbin1, 2;  Song, Yizhe1, 2;  Wang, Bing1, 2;  Wang, Shujun1;  Zhao, Shan1, 2;  Lv, Guojun1;  Ma, Xiaojun1
通讯作者: 吕国军 ;  马小军
关键词: alginate ;  biological applications of polymers ;  drug delivery systems ;  insulin ;  trypsin inhibitors
刊名: MACROMOLECULAR RAPID COMMUNICATIONS
发表日期: 2014-09-01
DOI: 10.1002/marc.201400267
卷: 35, 期:18, 页:1606-1610
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Polymer Science
研究领域[WOS]: Polymer Science
英文摘要: Sodium alginate (SA), acting as a trypsin inhibitor by means of electrostatic interaction, is studied. The half-maximal inhibitory concentration (IC50 = 0.05 mu g mL(-1)) of this natural anionic polymer is about 400 times lower than that of commercial soybean trypsin inhibitor (STI). Unlike the Ca2+-deprivation mechanisms, its inhibition may be attributed to preventing the trypsin active site (TAS) from accessing the macromolecular substrates instead of denaturing it. SA is an efficient, innocuous, and cost-effective inhibitory excipient that can be conveniently used in many peptide and protein dosage formulations.
关键词[WOS]: ORAL INSULIN DELIVERY ;  IN-VITRO ;  ENZYME ;  CALCIUM ;  MICROPARTICLES ;  NANOPARTICLES ;  DEGRADATION ;  HYDROGELS ;  PEPTIDES ;  PROTEINS
语种: 英语
WOS记录号: WOS:000342620700007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/144522
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Lv, Yan,Zhang, Jianbin,Song, Yizhe,et al. Natural Anionic Polymer Acts as Highly Efficient Trypsin Inhibitor Based on an Electrostatic Interaction Mechanism[J]. MACROMOLECULAR RAPID COMMUNICATIONS,2014,35(18):1606-1610.
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