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学科主题物理化学
Natural Anionic Polymer Acts as Highly Efficient Trypsin Inhibitor Based on an Electrostatic Interaction Mechanism
Lv, Yan1,2; Zhang, Jianbin1,2; Song, Yizhe1,2; Wang, Bing1,2; Wang, Shujun1; Zhao, Shan1,2; Lv, Guojun1; Ma, Xiaojun1; Lv GJ(吕国军); Ma XJ(马小军)
关键词Alginate Biological Applications Of Polymers Drug Delivery Systems Insulin Trypsin Inhibitors
刊名MACROMOLECULAR RAPID COMMUNICATIONS
2014-09-01
DOI10.1002/marc.201400267
35期:18页:1606-1610
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Polymer Science
研究领域[WOS]Polymer Science
关键词[WOS]ORAL INSULIN DELIVERY ; IN-VITRO ; ENZYME ; CALCIUM ; MICROPARTICLES ; NANOPARTICLES ; DEGRADATION ; HYDROGELS ; PEPTIDES ; PROTEINS
英文摘要Sodium alginate (SA), acting as a trypsin inhibitor by means of electrostatic interaction, is studied. The half-maximal inhibitory concentration (IC50 = 0.05 mu g mL(-1)) of this natural anionic polymer is about 400 times lower than that of commercial soybean trypsin inhibitor (STI). Unlike the Ca2+-deprivation mechanisms, its inhibition may be attributed to preventing the trypsin active site (TAS) from accessing the macromolecular substrates instead of denaturing it. SA is an efficient, innocuous, and cost-effective inhibitory excipient that can be conveniently used in many peptide and protein dosage formulations.
语种英语
WOS记录号WOS:000342620700007
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/144522
专题中国科学院大连化学物理研究所
通讯作者Lv GJ(吕国军); Ma XJ(马小军)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Lv, Yan,Zhang, Jianbin,Song, Yizhe,et al. Natural Anionic Polymer Acts as Highly Efficient Trypsin Inhibitor Based on an Electrostatic Interaction Mechanism[J]. MACROMOLECULAR RAPID COMMUNICATIONS,2014,35(18):1606-1610.
APA Lv, Yan.,Zhang, Jianbin.,Song, Yizhe.,Wang, Bing.,Wang, Shujun.,...&马小军.(2014).Natural Anionic Polymer Acts as Highly Efficient Trypsin Inhibitor Based on an Electrostatic Interaction Mechanism.MACROMOLECULAR RAPID COMMUNICATIONS,35(18),1606-1610.
MLA Lv, Yan,et al."Natural Anionic Polymer Acts as Highly Efficient Trypsin Inhibitor Based on an Electrostatic Interaction Mechanism".MACROMOLECULAR RAPID COMMUNICATIONS 35.18(2014):1606-1610.
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