Subject Area物理化学
非甾体抗炎镇痛协同前药及其制备方法; 非甾体抗炎镇痛协同前药及其制备方法; 非甾体抗炎镇痛协同前药及其制备方法; 非甾体抗炎镇痛协同前药及其制备方法
杨凌; 葛广波; 刘兆明; 张延延; 曹云峰; 朱亮亮
Application NumberCN201110187453.6
Patent NumberCN201110187453.6
Application Date2011-07-06
Rights Holder中国科学院大连化学物理研究所
PCT Attributes
Copyright Date2015-06-17
非甾体抗炎镇痛协同前药及其制备方法; 非甾体抗炎镇痛协同前药及其制备方法; 非甾体抗炎镇痛协同前药及其制备方法; 非甾体抗炎镇痛协同前药及其制备方法
Date Available2015-06-17
Other AbstractThe invention relates to an anti-inflammatory analgesia mutual prodrug of a non-steroidal antiinflammatory drug, which is characterized in that two drug molecules having non-steroidal antiinflammatory analgesia or antipyretic analgesia effects to be connected through ester keys. The anti-inflammatory analgesia mutual prodrug has a structural formula shown in the description, wherein R1 is an alkyl group or an aromatic substituent group. Compared with the existing anti-inflammatory analgesia mutual prodrug, the anti-inflammatory analgesia mutual prodrug is obvious in pharmacological activity, high in safety and explicit in metabolic products and progress in human bodies. | 非甾体抗炎镇痛协同前药,其特征在于:该协同前药通过酯键将两个具有非甾体抗炎镇痛或解热镇痛效应的药物分子相连接;其具有如下结构通式:?(1),其中:R1为烷基或芳香取代基。与已有非甾体抗炎药前体药物相比,本发明所述协同前药药效活性显著,安全性高,人体内代谢产物及体内进程明确。
Document Type专利
Recommended Citation
GB/T 7714
杨凌,葛广波,刘兆明,等. 非甾体抗炎镇痛协同前药及其制备方法, 非甾体抗炎镇痛协同前药及其制备方法, 非甾体抗炎镇痛协同前药及其制备方法, 非甾体抗炎镇痛协同前药及其制备方法. CN201110187453.6[P]. 2015-06-17.
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