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题名: Metabolomic study of raw and processed Atractylodes macrocephala Koidz by LC-MS
作者: Shan, Guo-Shun1;  Zhang, Liang-Xiao2;  Zhao, Qi-Miao3;  Xiao, Hong-Bin4;  Zhuo, Rong-Jie4;  Xu, Gang1;  Jiang, Hong5;  You, Xian-Min1, 2;  Jia, Tian-Zhu1
关键词: Atractylodes macrocephala Koidz ;  Processing mechanism ;  Chemical markers ;  Ultra performance liquid chromatography ;  tandem time of flight mass spectrometry ;  Multivariate statistical analysis
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2014-09-01
DOI: 10.1016/j.jpba.2014.05.010
卷: 98, 页:74-84
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: Bai-Zhu, the dried rhizome of Atractylodes macrocephala Koidz (AMK), is widely used as a tonic herbal in eastern Asia. It is commonly used as prepared slices in clinic by stir-frying with wheat bran (processed AMK). In the theories of traditional Chinese medicine (TCM), Bai-Zhu possesses significantly different therapeutic effects before and after processing. However, the molecular mechanics of this processing is still unknown. In this paper, the strategy of metabolomics was employed to investigate the changes of chemical constituents in Atractylodes macrocephala Koidz after processing. Meanwhile, the cell activity test variation of processed and unprocessed medicine was used to interpret the processing mechanism of AMK. Using ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOF/MS) with the method of multivariate statistic analyses including principal component analysis (PCA) and partial least square-discriminant analysis (PLS-DA), atractylenolide I, atractylenolide II, atractylenolide III, atractylenolide VI, 7-hydroxycoumarin, 8-beta-methoxy atractylenolide land Selina-4 (14), 7 (11)-dien-8-one were rapidly explored as the potential chemical markers of raw and processed AMK, respectively. Furthermore, it could be speculated that the processing mechanism of AMK was to increase the content of atractylenolide III which could strengthen the effect on gastrointestinal function. (C) 2014 Elsevier B.V. All rights reserved.
语种: 英语
WOS记录号: WOS:000339859800010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145420
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian 116600, Liaoning, Peoples R China
2.Chinese Acad Agr Sci, Oil Crops Res Inst, Wuhan 430062, Peoples R China
3.Liaoning Univ Tradit Chinese Med, Xinglin Coll, Shenyang 110167, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116623, Peoples R China
5.Med Res Inst Liaoning Prov, Shenyang 110034, Peoples R China

Recommended Citation:
Shan, Guo-Shun,Zhang, Liang-Xiao,Zhao, Qi-Miao,et al. Metabolomic study of raw and processed Atractylodes macrocephala Koidz by LC-MS[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2014,98:74-84.
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