DICP OpenIR
New insight into transmembrane topology of Staphylococcus aureus histidine kinase AgrC
Wang, Lina1; Quan, Chunshan2,3; Xiong, Wen2,3; Qu, Xiaojing2,3; Fan, Shengdi2,3; Hu, Wenzhong2,3
关键词Agrc Topology Gfp Scam Staphylococcus Aureus
刊名BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
2014-03-01
DOI10.1016/j.bbamem.2013.12.006
1838期:3页:988-993
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CYSTEINE ACCESSIBILITY METHOD ; MEMBRANE-PROTEIN TOPOGENESIS ; VIRULENCE GENES ; REGULATORY RNA ; UNITED-STATES ; RF CLONING ; RECEPTOR ; PREDICTION ; RECOGNITION ; IDENTIFICATION
英文摘要Staphylococcus aureus accessory gene regulator (agr) locus controls the expression of virulence factors through a classical two-component signal transduction system that consists of a receptor histidine protein kinase AgrC and a cytoplasmic response regulator AgrA. An autoinducing peptide (AIP) encoded by agr locus activates AgrC, which transduces extracellular signals into the cytoplasm. Despite extensive investigations to identify AgrC-AIP interaction sites, precise signal recognition mechanisms remain unknown. This study aims to clarify the membrane topology of AgrC by applying the green fluorescent protein (GFP) fusion technique and the substituted cysteine accessibility method (SCAM). However, our findings were inconsistent with profile obtained previously by alkaline phosphatase. We report the topology of AgrC shows seven transmembrane segments, a periplasmic N-terminus, and a cytoplasmic C-terminus. (C) 2013 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000331661800029
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/145426
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Dalian Nationalities Univ, Dept Life Sci, Dalian 116600, Peoples R China
3.State Ethn Affairs Commiss, Minist Educ Econ & Technol Dev Zone, Dalian 116600, Peoples R China
推荐引用方式
GB/T 7714
Wang, Lina,Quan, Chunshan,Xiong, Wen,et al. New insight into transmembrane topology of Staphylococcus aureus histidine kinase AgrC[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2014,1838(3):988-993.
APA Wang, Lina,Quan, Chunshan,Xiong, Wen,Qu, Xiaojing,Fan, Shengdi,&Hu, Wenzhong.(2014).New insight into transmembrane topology of Staphylococcus aureus histidine kinase AgrC.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,1838(3),988-993.
MLA Wang, Lina,et al."New insight into transmembrane topology of Staphylococcus aureus histidine kinase AgrC".BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1838.3(2014):988-993.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Lina]的文章
[Quan, Chunshan]的文章
[Xiong, Wen]的文章
百度学术
百度学术中相似的文章
[Wang, Lina]的文章
[Quan, Chunshan]的文章
[Xiong, Wen]的文章
必应学术
必应学术中相似的文章
[Wang, Lina]的文章
[Quan, Chunshan]的文章
[Xiong, Wen]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。