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Serum Metabolomics Study of the Acute Graft Rejection in Human Renal Transplantation Based on Liquid Chromatography-Mass Spectrometry
Zhao, Xinjie1; Chen, Jihong2; Ye, Lei2; Xu, Guowang1
KeywordMetabolomics Hilic Rplc Acute Graft Rejection Renal Transplantation
Source PublicationJOURNAL OF PROTEOME RESEARCH
2014-05-01
DOI10.1021/pr5001048
Volume13Issue:5Pages:2659-2667
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemical Research Methods
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordINDOLEAMINE 2,3-DIOXYGENASE ; KIDNEY-TRANSPLANTS ; METABONOMIC ANALYSIS ; CELL PROLIFERATION ; PHOSPHOLIPASE A(2) ; XANTHINE-OXIDASE ; IMMUNE FUNCTION ; CYCLOSPORINE-A ; BILE-ACIDS ; T-CELL
AbstractAcute graft rejection is one of the most common and serious postcomplications in renal transplantation. A noninvasive method is needed to specifically monitor acute graft rejection. We investigated metabolic alterations of acute graft rejection in human renal transplantation by applying a metabolomics approach. Sera from 11 acute graft rejection subjects and 16 nonacute graft rejection subjects were analyzed by a nontargeted liquid chromatography mass spectrometry (LC-MS) metabolomics approach including both hydrophilic interaction chromatography and reversed-phase liquid chromatography separations. Discriminative metabolites of acute graft rejection after transplantation were detected, including creatinine, kynurenine, uric acid, polyunsaturated fatty acid, phosphatidylcholines, sphingomyelins, lysophosphatidylcholines, etc. The lower level of serum dehydroepiandrosterone sulfate was found in the acute graft rejection group before transplantation. The results revealed comprehensive metabolic abnormalities in acute graft rejection. The findings are valuable for the clinic noninvasive diagnosis or therapy of acute graft rejection.
Language英语
WOS IDWOS:000335490600035
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/145504
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Xinjiang Med Univ, Hosp 1, Dept Nephrol, Urumqi 830054, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Xinjie,Chen, Jihong,Ye, Lei,et al. Serum Metabolomics Study of the Acute Graft Rejection in Human Renal Transplantation Based on Liquid Chromatography-Mass Spectrometry[J]. JOURNAL OF PROTEOME RESEARCH,2014,13(5):2659-2667.
APA Zhao, Xinjie,Chen, Jihong,Ye, Lei,&Xu, Guowang.(2014).Serum Metabolomics Study of the Acute Graft Rejection in Human Renal Transplantation Based on Liquid Chromatography-Mass Spectrometry.JOURNAL OF PROTEOME RESEARCH,13(5),2659-2667.
MLA Zhao, Xinjie,et al."Serum Metabolomics Study of the Acute Graft Rejection in Human Renal Transplantation Based on Liquid Chromatography-Mass Spectrometry".JOURNAL OF PROTEOME RESEARCH 13.5(2014):2659-2667.
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