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题名: Serum Metabolomics Study of the Acute Graft Rejection in Human Renal Transplantation Based on Liquid Chromatography-Mass Spectrometry
作者: Zhao, Xinjie1;  Chen, Jihong2;  Ye, Lei2;  Xu, Guowang1
关键词: metabolomics ;  HILIC ;  RPLC ;  acute graft rejection ;  renal transplantation
刊名: JOURNAL OF PROTEOME RESEARCH
发表日期: 2014-05-01
DOI: 10.1021/pr5001048
卷: 13, 期:5, 页:2659-2667
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemical Research Methods
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: Acute graft rejection is one of the most common and serious postcomplications in renal transplantation. A noninvasive method is needed to specifically monitor acute graft rejection. We investigated metabolic alterations of acute graft rejection in human renal transplantation by applying a metabolomics approach. Sera from 11 acute graft rejection subjects and 16 nonacute graft rejection subjects were analyzed by a nontargeted liquid chromatography mass spectrometry (LC-MS) metabolomics approach including both hydrophilic interaction chromatography and reversed-phase liquid chromatography separations. Discriminative metabolites of acute graft rejection after transplantation were detected, including creatinine, kynurenine, uric acid, polyunsaturated fatty acid, phosphatidylcholines, sphingomyelins, lysophosphatidylcholines, etc. The lower level of serum dehydroepiandrosterone sulfate was found in the acute graft rejection group before transplantation. The results revealed comprehensive metabolic abnormalities in acute graft rejection. The findings are valuable for the clinic noninvasive diagnosis or therapy of acute graft rejection.
关键词[WOS]: INDOLEAMINE 2,3-DIOXYGENASE ;  KIDNEY-TRANSPLANTS ;  METABONOMIC ANALYSIS ;  CELL PROLIFERATION ;  PHOSPHOLIPASE A(2) ;  XANTHINE-OXIDASE ;  IMMUNE FUNCTION ;  CYCLOSPORINE-A ;  BILE-ACIDS ;  T-CELL
语种: 英语
WOS记录号: WOS:000335490600035
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145504
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Xinjiang Med Univ, Hosp 1, Dept Nephrol, Urumqi 830054, Peoples R China

Recommended Citation:
Zhao, Xinjie,Chen, Jihong,Ye, Lei,et al. Serum Metabolomics Study of the Acute Graft Rejection in Human Renal Transplantation Based on Liquid Chromatography-Mass Spectrometry[J]. JOURNAL OF PROTEOME RESEARCH,2014,13(5):2659-2667.
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