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Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-kappa B and endothelial inflammatory response
Li, Yu1,2,3; Liu, Hongtao3; Xu, Qing-Song1; Du, Yu-Guang1; Xu, Jian3
关键词Chitosan Oligosaccharides Lipopolysaccharides (Lps) Endothelial Cells O-glcnacylation Nuclear Factor Kappa-light-chain-enhancer Of Activated b Cells (Nf-kappa b) Inflammatory Response
刊名CARBOHYDRATE POLYMERS
2014-01-02
DOI10.1016/j.carbpol.2013.08.082
99页:568-578
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Chemistry ; Polymer Science
关键词[WOS]IN-VITRO ; NUCLEOCYTOPLASMIC PROTEINS ; GLCNAC MODIFICATION ; INSULIN-RESISTANCE ; SIGNALING PATHWAY ; OXIDATIVE STRESS ; IMMUNE-SYSTEM ; CELLS ; ACTIVATION ; CHITOOLIGOSACCHARIDES
英文摘要It is known that chitosan oligosaccharides (COS) suppress LPS-induced vascular endothelial inflammatory response by mechanism involving NF-kappa B blockade. It remains unknown how COS inhibit NF-kappa B. We provided evidence both in cultured endothelial cells and mouse model supporting a new mechanism. Regardless of the endothelial cell types, the LPS-induced NF-kappa B-dependent inflammatory gene expression was suppressed by COS, which was associated with reduced NF-kappa B nucleus translocation. LPS enhanced O-GlcNAc modification of NF-kappa B/p65 and activated NF-kappa B pathway, which could be prevented either by siRNA knockdown of O-GlcNAc transferase (OGT) or pretreatment with COS. Inhibition of either mitogen-activated protein kinase or superoxide generation abolishes LPS-induced NF-kappa B O-GlcNAcylation. Consistently, aortic tissues from LPS-treated mice presented enhanced NF-kappa B/p65 O-GlcNAcylation in association with upregulated gene expression of inflammatory cytokines in vascular tissues; however, pre-administration of COS prevented these responses. In conclusion, COS decreased OGT-dependent O-GlcNAcylation of NF-kappa B and thereby attenuated LPS-induced vascular endothelial inflammatory response. (C) 2013 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000329256600073
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被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/145521
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Univ Oklahoma, Hlth Sci Ctr, Dept Med, Oklahoma City, OK 73104 USA
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Li, Yu,Liu, Hongtao,Xu, Qing-Song,et al. Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-kappa B and endothelial inflammatory response[J]. CARBOHYDRATE POLYMERS,2014,99:568-578.
APA Li, Yu,Liu, Hongtao,Xu, Qing-Song,Du, Yu-Guang,&Xu, Jian.(2014).Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-kappa B and endothelial inflammatory response.CARBOHYDRATE POLYMERS,99,568-578.
MLA Li, Yu,et al."Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-kappa B and endothelial inflammatory response".CARBOHYDRATE POLYMERS 99(2014):568-578.
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