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题名: Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-kappa B and endothelial inflammatory response
作者: Li, Yu1, 2, 3;  Liu, Hongtao3;  Xu, Qing-Song1;  Du, Yu-Guang1;  Xu, Jian3
关键词: Chitosan oligosaccharides ;  Lipopolysaccharides (LPS) ;  Endothelial cells ;  O-GlcNAcylation ;  Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) ;  Inflammatory response
刊名: CARBOHYDRATE POLYMERS
发表日期: 2014-01-02
DOI: 10.1016/j.carbpol.2013.08.082
卷: 99, 页:568-578
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: It is known that chitosan oligosaccharides (COS) suppress LPS-induced vascular endothelial inflammatory response by mechanism involving NF-kappa B blockade. It remains unknown how COS inhibit NF-kappa B. We provided evidence both in cultured endothelial cells and mouse model supporting a new mechanism. Regardless of the endothelial cell types, the LPS-induced NF-kappa B-dependent inflammatory gene expression was suppressed by COS, which was associated with reduced NF-kappa B nucleus translocation. LPS enhanced O-GlcNAc modification of NF-kappa B/p65 and activated NF-kappa B pathway, which could be prevented either by siRNA knockdown of O-GlcNAc transferase (OGT) or pretreatment with COS. Inhibition of either mitogen-activated protein kinase or superoxide generation abolishes LPS-induced NF-kappa B O-GlcNAcylation. Consistently, aortic tissues from LPS-treated mice presented enhanced NF-kappa B/p65 O-GlcNAcylation in association with upregulated gene expression of inflammatory cytokines in vascular tissues; however, pre-administration of COS prevented these responses. In conclusion, COS decreased OGT-dependent O-GlcNAcylation of NF-kappa B and thereby attenuated LPS-induced vascular endothelial inflammatory response. (C) 2013 Elsevier Ltd. All rights reserved.
关键词[WOS]: IN-VITRO ;  NUCLEOCYTOPLASMIC PROTEINS ;  GLCNAC MODIFICATION ;  INSULIN-RESISTANCE ;  SIGNALING PATHWAY ;  OXIDATIVE STRESS ;  IMMUNE-SYSTEM ;  CELLS ;  ACTIVATION ;  CHITOOLIGOSACCHARIDES
语种: 英语
WOS记录号: WOS:000329256600073
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145521
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Univ Oklahoma, Hlth Sci Ctr, Dept Med, Oklahoma City, OK 73104 USA

Recommended Citation:
Li, Yu,Liu, Hongtao,Xu, Qing-Song,et al. Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-kappa B and endothelial inflammatory response[J]. CARBOHYDRATE POLYMERS,2014,99:568-578.
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