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题名: Structural characterisation of algae Costaria costata fucoidan and its effects on CCl4-induced liver injury
作者: Wang, Qiukuan1;  Song, Yuefan1;  He, Yunhai1;  Ren, Dandan1;  Kow, Felicia2;  Qiao, Zhiyong1;  Liu, Shu1;  Yu, Xingju3
关键词: Costaria costata ;  Fucoidan ;  Structural characterisation ;  Liver injury
刊名: CARBOHYDRATE POLYMERS
发表日期: 2014-07-17
DOI: 10.1016/j.carbpol.2014.02.071
卷: 107, 页:247-254
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: Fucoidan is a well-known natural product that is commonly found in brown algae and shows a variety of activities, including immunomodulation, antioxidation, and the combat of carcinogens. The fucoidan fractions of Costaria costata, a brown algae introduced from Japan and cultured in northern China, were studied. The fucoidan fractions were extracted, separated, and purified using a combinatorial procedure consisting of enzymolysis, ethanol precipitation, and DEAE and size-exclusion chromatographies. The fundamental characteristics of the four enriched fucoidan fractions (F1-F4), such as their sulphate content and monosaccharide composition, were investigated. FTIR and NMR spectroscopy were employed to further elucidate the structural features of the four fractions. It was found that the F1-F4 fractions all showed oxidative activity against hydroxyl radicals. The bioactive effects of the fucoidan fractions on CCl4-induced liver injury suggest their potential use as ingredients for functional foods or pharmaceuticals. (C) 2014 Elsevier Ltd. All rights reserved.
关键词[WOS]: BROWN SEAWEED ;  LAMINARIA-JAPONICA ;  SULFATED POLYSACCHARIDES ;  UNDARIA-PINNATIFIDA ;  ANTIOXIDANT ACTIVITY ;  ANTITUMOR-ACTIVITY ;  IN-VITRO ;  ANTICOAGULANT ;  SPOROPHYLL ;  FRACTIONS
语种: 英语
WOS记录号: WOS:000335103900032
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145525
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Ocean Univ, Key Lab Aquat Prod Proc & Utilisat Leaning Prov, Dalian 116023, Peoples R China
2.Australian Maritime Coll, Launceston, Tas 7250, Australia
3.Chinese Acad Sci, Dalian Inst Chem Phys, Marine Bioprod Engn Grp, Beijing 100864, Peoples R China

Recommended Citation:
Wang, Qiukuan,Song, Yuefan,He, Yunhai,et al. Structural characterisation of algae Costaria costata fucoidan and its effects on CCl4-induced liver injury[J]. CARBOHYDRATE POLYMERS,2014,107:247-254.
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