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题名: Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography-Mass Spectrometry
作者: Zhao, Xinjie1;  Xu, Fang2;  Qi, Bing3;  Hao, Songli2;  Li, Yanjie1;  Li, Yan2;  Zou, Lihong4;  Lu, Caixia2;  Xu, Guowang1;  Hou, Lihui2
关键词: Metabolomics ;  LC-MS ;  polycystic ovary syndrome ;  biomarkers
刊名: JOURNAL OF PROTEOME RESEARCH
发表日期: 2014-02-01
DOI: 10.1021/pr401130w
卷: 13, 期:2, 页:1101-1111
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemical Research Methods
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: Polycystic ovary syndrome (PCOS) is a complex, heterogeneous disorder, which produces in 5-10% reproductive age women. In this study, a nontargeted metabolomics approach based on ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry is used to investigate serum metabolic characteristics of PCOS. PCOS women and healthy control can be clustered into two distinct groups based on multivariate statistical analysis. Significant increase in the levels of unsaturated free fatty acids, fatty acid amides, sulfated steroids, glycated amino acid and the decrease in levels of lysophosphatidylcholines, lysophosphatidylethanolamines, etc., were found. These metabolites showed abnormalities of lipid- and androgen-metabolism, increase of stearoyl-CoA desaturase (SCD) activity and accumulation of advanced glycation end-products in PCOS patients. On the basis of the binary logistic regression model, free fatty acid (FFA) 18:1/FFA 18:0, FFA 20:3, dihydrotestosterone sulfate, glycated phenylalanine, and uridine were combined as a diagnostic biomarker. The area under the curve (AUC) of combinational biomarker was 0.839 in 131 discovery phase samples and 0.874 in 109 validation phase samples. The findings of our study offer a new insight to understand the pathogenesis mechanism, and the discriminating metabolites may provide a prospect for PCOS diagnosis.
关键词[WOS]: STEAROYL-COA DESATURASE ;  GLYCATION END-PRODUCTS ;  FREE FATTY-ACIDS ;  DEHYDROEPIANDROSTERONE-SULFATE ;  INSULIN-RESISTANCE ;  CHRONIC INFLAMMATION ;  LUTEINIZING-HORMONE ;  OXIDATIVE STRESS ;  SYNDROME PCOS ;  CANCER-RISK
语种: 英语
WOS记录号: WOS:000331164100068
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145531
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Gynaecol Clin, Harbin 150040, Peoples R China
3.Beijing Univ Chinese Med, Subsidiary Dongfang Hosp, Beijing 100078, Peoples R China
4.Med Univ, Affiliated Hosp 1, Harbin 150001, Peoples R China

Recommended Citation:
Zhao, Xinjie,Xu, Fang,Qi, Bing,et al. Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography-Mass Spectrometry[J]. JOURNAL OF PROTEOME RESEARCH,2014,13(2):1101-1111.
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