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Copolymer-grafted silica phase from a cation-anion monomer pair for enhanced separation in reversed-phase liquid chromatography
Mallik, Abul K.1; Qiu, Hongdeng3,4; Takafuji, Makoto1,2; Ihara, Hirotaka1,2
关键词Reversed-phase Chromatography Ionic Liquid-modified Silica Molecular-shape Selectivity Carbonyl-pi Interaction Polycyclic Aromatic Hydrocarbons Nucleosides
刊名ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2014-05-01
DOI10.1007/s00216-014-7765-0
406期:14页:3507-3515
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]POLYCYCLIC AROMATIC-HYDROCARBONS ; STATIONARY-PHASE ; IONIC LIQUIDS ; RADICAL POLYMERIZATION ; RETENTION BEHAVIOR ; SHAPE SELECTIVITY ; PERFORMANCE ; NUCLEOSIDES ; TOXICITY ; EXCHANGE
英文摘要This work reports a new imidazolium and l-alanine derived copolymer-grafted silica stationary phase for ready separation of complex isomers using high-performance liquid chromatography (HPLC). For this purpose, 1-allyl-3-octadecylimidazolium bromide ([AyImC(18)]Br) and N-acryloyl-l-alanine sodium salt ([AAL]Na) ionic liquids (IL) monomers were synthesized. Subsequently, the bromide counteranion was exchanged with the 2-(acrylamido)propanoate organic counteranion by reacting the [AyImC(18)]Br with excess [AAL]Na in water. The obtained IL cation-anion monomer pair was then copolymerized on mercaptopropyl-modified silica (Sil-MPS) via a surface-initiated radical chain-transfer reaction. The selective retention behaviors of polycyclic aromatic hydrocarbons (PAHs), including some positional isomers, steroids, and nucleobases were investigated using the newly obtained Sil-poly(ImC(18)-AAL), and octadecyl silylated silica (ODS) was used as the reference column. Interesting results were obtained for the separation of PAHs, steroids, and nucleobases with the new organic phase. The results showed that the Sil-poly(ImC(18)-AAL) presented multiple noncovalent interactions, including hydrophobic, pi-pi, carbonyl-pi, and ion-dipole interactions for the separation of PAHs and dipolar compounds. Only pure water was sufficient as the mobile phase for the separation of the nucleobases. Ten nucleosides and bases were separated, using only water as the mobile phase, within a very short time using the Sil-poly(ImC(18)-AAL), which is otherwise difficult to achieve using conventional hydrophobic columns such as ODS. The combination of electrostatic and hydrophobic interactions are important for the effective separation of such basic compounds without the use of any organic additive as the eluent on the Sil-poly(ImC(18)-AAL) column.
语种英语
WOS记录号WOS:000336261800028
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/145537
专题中国科学院大连化学物理研究所
作者单位1.Kumamoto Univ, Fac Engn, Dept Appl Chem & Biochem, Kumamoto 8608555, Japan
2.Kumamoto Inst Photoelectroorgan Phoen, Kumamoto 8620901, Japan
3.Chinese Acad Sci, Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China
4.Chinese Acad Sci, Inst Chem Phys, Key Lab Nat Med Gansu Prov Lanzhou, Lanzhou 730000, Peoples R China
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GB/T 7714
Mallik, Abul K.,Qiu, Hongdeng,Takafuji, Makoto,et al. Copolymer-grafted silica phase from a cation-anion monomer pair for enhanced separation in reversed-phase liquid chromatography[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2014,406(14):3507-3515.
APA Mallik, Abul K.,Qiu, Hongdeng,Takafuji, Makoto,&Ihara, Hirotaka.(2014).Copolymer-grafted silica phase from a cation-anion monomer pair for enhanced separation in reversed-phase liquid chromatography.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,406(14),3507-3515.
MLA Mallik, Abul K.,et al."Copolymer-grafted silica phase from a cation-anion monomer pair for enhanced separation in reversed-phase liquid chromatography".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 406.14(2014):3507-3515.
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