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题名: Copolymer-grafted silica phase from a cation-anion monomer pair for enhanced separation in reversed-phase liquid chromatography
作者: Mallik, Abul K.1;  Qiu, Hongdeng3, 4;  Takafuji, Makoto1, 2;  Ihara, Hirotaka1, 2
关键词: Reversed-phase chromatography ;  Ionic liquid-modified silica ;  Molecular-shape selectivity ;  Carbonyl-pi interaction ;  Polycyclic aromatic hydrocarbons ;  Nucleosides
刊名: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
发表日期: 2014-05-01
DOI: 10.1007/s00216-014-7765-0
卷: 406, 期:14, 页:3507-3515
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: This work reports a new imidazolium and l-alanine derived copolymer-grafted silica stationary phase for ready separation of complex isomers using high-performance liquid chromatography (HPLC). For this purpose, 1-allyl-3-octadecylimidazolium bromide ([AyImC(18)]Br) and N-acryloyl-l-alanine sodium salt ([AAL]Na) ionic liquids (IL) monomers were synthesized. Subsequently, the bromide counteranion was exchanged with the 2-(acrylamido)propanoate organic counteranion by reacting the [AyImC(18)]Br with excess [AAL]Na in water. The obtained IL cation-anion monomer pair was then copolymerized on mercaptopropyl-modified silica (Sil-MPS) via a surface-initiated radical chain-transfer reaction. The selective retention behaviors of polycyclic aromatic hydrocarbons (PAHs), including some positional isomers, steroids, and nucleobases were investigated using the newly obtained Sil-poly(ImC(18)-AAL), and octadecyl silylated silica (ODS) was used as the reference column. Interesting results were obtained for the separation of PAHs, steroids, and nucleobases with the new organic phase. The results showed that the Sil-poly(ImC(18)-AAL) presented multiple noncovalent interactions, including hydrophobic, pi-pi, carbonyl-pi, and ion-dipole interactions for the separation of PAHs and dipolar compounds. Only pure water was sufficient as the mobile phase for the separation of the nucleobases. Ten nucleosides and bases were separated, using only water as the mobile phase, within a very short time using the Sil-poly(ImC(18)-AAL), which is otherwise difficult to achieve using conventional hydrophobic columns such as ODS. The combination of electrostatic and hydrophobic interactions are important for the effective separation of such basic compounds without the use of any organic additive as the eluent on the Sil-poly(ImC(18)-AAL) column.
关键词[WOS]: POLYCYCLIC AROMATIC-HYDROCARBONS ;  STATIONARY-PHASE ;  IONIC LIQUIDS ;  RADICAL POLYMERIZATION ;  RETENTION BEHAVIOR ;  SHAPE SELECTIVITY ;  PERFORMANCE ;  NUCLEOSIDES ;  TOXICITY ;  EXCHANGE
语种: 英语
WOS记录号: WOS:000336261800028
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145537
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Kumamoto Univ, Fac Engn, Dept Appl Chem & Biochem, Kumamoto 8608555, Japan
2.Kumamoto Inst Photoelectroorgan Phoen, Kumamoto 8620901, Japan
3.Chinese Acad Sci, Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China
4.Chinese Acad Sci, Inst Chem Phys, Key Lab Nat Med Gansu Prov Lanzhou, Lanzhou 730000, Peoples R China

Recommended Citation:
Mallik, Abul K.,Qiu, Hongdeng,Takafuji, Makoto,et al. Copolymer-grafted silica phase from a cation-anion monomer pair for enhanced separation in reversed-phase liquid chromatography[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2014,406(14):3507-3515.
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