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Discovery of N-methyltetrahydroprotoberberines with kappa-opioid receptor agonists-opioid receptor agonist activities from corydalis yanhusuo W. T. Wang by using two-dimensional liquid chromatography
Zhang, Yan1; Wang, Chaoran2; Guo, Zhimou2; Zhang, Xiuli2; Wang, Zhiwei1; Liang, Xinmiao2,3; Civelli, Olivier1,4,5
关键词Gpcr Tcms 2d Separation Corydalis Yanhusuo Wt Wang Kappa-opioid Receptor
刊名JOURNAL OF ETHNOPHARMACOLOGY
2014-09-29
DOI10.1016/j.jep.2014.07.057
155期:3页:1597-1602
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]NATURAL-PRODUCTS ; ALKALOIDS ; PURIFICATION ; SEPARATION ; PHASE ; MEDICINE ; SYSTEM ; COLUMN ; PAIN
英文摘要Ethnopharmacological relevance: The need for an efficacious analgesic without unwanted side effects is urgent. kappa-opioid receptor agonists are known to exhibit potent analgesic effects and elicited fewer side effects than other opioid agonists. Thus in this study we chose the kappa-opioid receptor as the target to identify the active components from traditional Chinese medicines (TCMs).
语种英语
WOS记录号WOS:000343380300023
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/145544
专题中国科学院大连化学物理研究所
作者单位1.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
4.Univ Calif Irvine, Dept Pharmacol Sci, Irvine, CA 92697 USA
5.Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA
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Zhang, Yan,Wang, Chaoran,Guo, Zhimou,et al. Discovery of N-methyltetrahydroprotoberberines with kappa-opioid receptor agonists-opioid receptor agonist activities from corydalis yanhusuo W. T. Wang by using two-dimensional liquid chromatography[J]. JOURNAL OF ETHNOPHARMACOLOGY,2014,155(3):1597-1602.
APA Zhang, Yan.,Wang, Chaoran.,Guo, Zhimou.,Zhang, Xiuli.,Wang, Zhiwei.,...&Civelli, Olivier.(2014).Discovery of N-methyltetrahydroprotoberberines with kappa-opioid receptor agonists-opioid receptor agonist activities from corydalis yanhusuo W. T. Wang by using two-dimensional liquid chromatography.JOURNAL OF ETHNOPHARMACOLOGY,155(3),1597-1602.
MLA Zhang, Yan,et al."Discovery of N-methyltetrahydroprotoberberines with kappa-opioid receptor agonists-opioid receptor agonist activities from corydalis yanhusuo W. T. Wang by using two-dimensional liquid chromatography".JOURNAL OF ETHNOPHARMACOLOGY 155.3(2014):1597-1602.
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