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题名: Discovery of N-methyltetrahydroprotoberberines with kappa-opioid receptor agonists-opioid receptor agonist activities from corydalis yanhusuo W. T. Wang by using two-dimensional liquid chromatography
作者: Zhang, Yan1;  Wang, Chaoran2;  Guo, Zhimou2;  Zhang, Xiuli2;  Wang, Zhiwei1;  Liang, Xinmiao2, 3;  Civelli, Olivier1, 4, 5
关键词: GPCR ;  TCMs ;  2D separation ;  Corydalis yanhusuo WT Wang ;  kappa-opioid receptor
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2014-09-29
DOI: 10.1016/j.jep.2014.07.057
卷: 155, 期:3, 页:1597-1602
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Integrative & Complementary Medicine ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy ;  Integrative & Complementary Medicine
英文摘要: Ethnopharmacological relevance: The need for an efficacious analgesic without unwanted side effects is urgent. kappa-opioid receptor agonists are known to exhibit potent analgesic effects and elicited fewer side effects than other opioid agonists. Thus in this study we chose the kappa-opioid receptor as the target to identify the active components from traditional Chinese medicines (TCMs).
关键词[WOS]: NATURAL-PRODUCTS ;  ALKALOIDS ;  PURIFICATION ;  SEPARATION ;  PHASE ;  MEDICINE ;  SYSTEM ;  COLUMN ;  PAIN
语种: 英语
WOS记录号: WOS:000343380300023
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145544
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
4.Univ Calif Irvine, Dept Pharmacol Sci, Irvine, CA 92697 USA
5.Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA

Recommended Citation:
Zhang, Yan,Wang, Chaoran,Guo, Zhimou,et al. Discovery of N-methyltetrahydroprotoberberines with kappa-opioid receptor agonists-opioid receptor agonist activities from corydalis yanhusuo W. T. Wang by using two-dimensional liquid chromatography[J]. JOURNAL OF ETHNOPHARMACOLOGY,2014,155(3):1597-1602.
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