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题名: Spatial blockage of ionic current for electrophoretic translocation of DNA through a graphene nanopore
作者: Lv, Wenping1;  Liu, Shengju1;  Li, Xin1;  Wu, Ren'an1
关键词: DNA sequencing ;  Graphene nanopore ;  Molecular dynamics simulation ;  Noise of ionic current ;  Translocation status of DNA
刊名: ELECTROPHORESIS
发表日期: 2014-04-01
DOI: 10.1002/elps.201300501
卷: 35, 期:8, 页:1144-1151
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Graphene nanopore has been promising the ultra-high resolution for DNA sequencing due to the atomic thickness and excellent electronic properties of the graphene monolayer. The dynamical translocation phenomena and/or behaviors underneath the blocked ionic current, however, have not been well unveiled to date for the translocation of DNA electrophoretically through a graphene nanopore. In this report, the assessment on the sensitivity of ionic current to instantaneous statuses of DNA in a 2.4 nm graphene nanopore was carried out based on the all-atom molecular dynamics simulations. By filtering out the thermal noise of ionic current, the instantaneous conformational variations of DNA in a graphene nanopore have been unveiled from the fluctuations of ionic current, because of the spatial blockage effect of DNA against ionic current. Interestingly, the neighborhood effect of DNA against ionic current was also observed within a distance of 1.5 nm nearby the graphene nanopore, suggesting the further precise control for DNA translocation through a graphene nanopore in gene sequencing. Moreover, the sensitivity of the blocked ionic current toward the instantaneous conformations of DNA in a graphene nanopore demonstrates the great potential of graphene nanopores in the dynamics analysis of single molecules.
关键词[WOS]: SOLID-STATE NANOPORES ;  MOLECULAR-DYNAMICS ;  SIMULATIONS ;  CHALLENGES ;  SENSORS
语种: 英语
WOS记录号: WOS:000334126600009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145548
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China

Recommended Citation:
Lv, Wenping,Liu, Shengju,Li, Xin,et al. Spatial blockage of ionic current for electrophoretic translocation of DNA through a graphene nanopore[J]. ELECTROPHORESIS,2014,35(8):1144-1151.
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