DICP OpenIR
Spatial blockage of ionic current for electrophoretic translocation of DNA through a graphene nanopore
Lv, Wenping; Liu, Shengju; Li, Xin; Wu, Ren'an
KeywordDna Sequencing Graphene Nanopore Molecular Dynamics Simulation Noise Of Ionic Current Translocation Status Of Dna
Source PublicationELECTROPHORESIS
2014-04-01
DOI10.1002/elps.201300501
Volume35Issue:8Pages:1144-1151
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordSOLID-STATE NANOPORES ; MOLECULAR-DYNAMICS ; SIMULATIONS ; CHALLENGES ; SENSORS
AbstractGraphene nanopore has been promising the ultra-high resolution for DNA sequencing due to the atomic thickness and excellent electronic properties of the graphene monolayer. The dynamical translocation phenomena and/or behaviors underneath the blocked ionic current, however, have not been well unveiled to date for the translocation of DNA electrophoretically through a graphene nanopore. In this report, the assessment on the sensitivity of ionic current to instantaneous statuses of DNA in a 2.4 nm graphene nanopore was carried out based on the all-atom molecular dynamics simulations. By filtering out the thermal noise of ionic current, the instantaneous conformational variations of DNA in a graphene nanopore have been unveiled from the fluctuations of ionic current, because of the spatial blockage effect of DNA against ionic current. Interestingly, the neighborhood effect of DNA against ionic current was also observed within a distance of 1.5 nm nearby the graphene nanopore, suggesting the further precise control for DNA translocation through a graphene nanopore in gene sequencing. Moreover, the sensitivity of the blocked ionic current toward the instantaneous conformations of DNA in a graphene nanopore demonstrates the great potential of graphene nanopores in the dynamics analysis of single molecules.
Language英语
WOS IDWOS:000334126600009
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/145548
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Lv, Wenping,Liu, Shengju,Li, Xin,et al. Spatial blockage of ionic current for electrophoretic translocation of DNA through a graphene nanopore[J]. ELECTROPHORESIS,2014,35(8):1144-1151.
APA Lv, Wenping,Liu, Shengju,Li, Xin,&Wu, Ren'an.(2014).Spatial blockage of ionic current for electrophoretic translocation of DNA through a graphene nanopore.ELECTROPHORESIS,35(8),1144-1151.
MLA Lv, Wenping,et al."Spatial blockage of ionic current for electrophoretic translocation of DNA through a graphene nanopore".ELECTROPHORESIS 35.8(2014):1144-1151.
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