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题名: Marine phytoplankton motility sensor integrated into a microfluidic chip for high-throughput pollutant toxicity assessment
作者: Zheng, Guo-xia1, 3;  Li, Ya-jie2, 3;  Qi, Lin-lin1, 2;  Liu, Xian-ming3, 4;  Wang, Hu1, 3;  Yu, Shu-ping1, 3;  Wang, Yun-hua2, 3
关键词: Microfluidic chip ;  Marine phytoplankton ;  Motility ;  Toxicity assessment ;  High-throughput
刊名: MARINE POLLUTION BULLETIN
发表日期: 2014-07-15
DOI: 10.1016/j.marpolbul.2014.05.019
卷: 84, 期:1-2, 页:147-154
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Environmental Sciences ;  Marine & Freshwater Biology
研究领域[WOS]: Environmental Sciences & Ecology ;  Marine & Freshwater Biology
英文摘要: A microfluidic chip was designed to assess the toxicity of pollutants in a high-throughput way by using marine phytoplankton motility as a sensor signal. In this chip, multiple gradient generators (CGGs) with diffusible chambers enable large scale of dose-response bioassays to be performed in a simple way. Two mobile marine phytoplankton cells were confined on-chip and stimulated by 8 concentrations (generated by CGG) of Hg, Pb, Cu and phenol singly, as well as Cu and phenol jointly. CASA system was used to characterize motility by motile percentage (%MOT), curvilinear velocity (VCL), average path velocity (VAP) and straight line velocity (VSL). In all cases, dose-dependent inhibitions of motility were observed. In the present system, only 2 h was needed to predict EC50. Thus, the developed microfluidic chip device was proved to be useful as a rapid/simple and high-throughput test method in marine pollution toxicity assessment. (C) 2014 Elsevier Ltd. All rights reserved.
关键词[WOS]: SPERM MOTILITY ;  DAPHNIA-MAGNA ;  HEAVY-METALS ;  ALGAE ;  COPPER ;  CHLAMYDOMONAS ;  MICROALGAE ;  CHEMICALS ;  BACTERIA ;  CADMIUM
语种: 英语
WOS记录号: WOS:000338804700030
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145572
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ, Chem & Environm Engn Inst, Dalian 116012, Peoples R China
2.Dalian Univ, Sch Med, Dalian 116012, Peoples R China
3.Dalian Univ, Microfluid Res Inst, Dalian 116012, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China

Recommended Citation:
Zheng, Guo-xia,Li, Ya-jie,Qi, Lin-lin,et al. Marine phytoplankton motility sensor integrated into a microfluidic chip for high-throughput pollutant toxicity assessment[J]. MARINE POLLUTION BULLETIN,2014,84(1-2):147-154.
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