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Marine phytoplankton motility sensor integrated into a microfluidic chip for high-throughput pollutant toxicity assessment
Zheng, Guo-xia1,3; Li, Ya-jie2,3; Qi, Lin-lin1,2; Liu, Xian-ming3,4; Wang, Hu1,3; Yu, Shu-ping1,3; Wang, Yun-hua2,3
关键词Microfluidic Chip Marine Phytoplankton Motility Toxicity Assessment High-throughput
刊名MARINE POLLUTION BULLETIN
2014-07-15
DOI10.1016/j.marpolbul.2014.05.019
84期:1-2页:147-154
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Environmental Sciences ; Marine & Freshwater Biology
研究领域[WOS]Environmental Sciences & Ecology ; Marine & Freshwater Biology
关键词[WOS]SPERM MOTILITY ; DAPHNIA-MAGNA ; HEAVY-METALS ; ALGAE ; COPPER ; CHLAMYDOMONAS ; MICROALGAE ; CHEMICALS ; BACTERIA ; CADMIUM
英文摘要A microfluidic chip was designed to assess the toxicity of pollutants in a high-throughput way by using marine phytoplankton motility as a sensor signal. In this chip, multiple gradient generators (CGGs) with diffusible chambers enable large scale of dose-response bioassays to be performed in a simple way. Two mobile marine phytoplankton cells were confined on-chip and stimulated by 8 concentrations (generated by CGG) of Hg, Pb, Cu and phenol singly, as well as Cu and phenol jointly. CASA system was used to characterize motility by motile percentage (%MOT), curvilinear velocity (VCL), average path velocity (VAP) and straight line velocity (VSL). In all cases, dose-dependent inhibitions of motility were observed. In the present system, only 2 h was needed to predict EC50. Thus, the developed microfluidic chip device was proved to be useful as a rapid/simple and high-throughput test method in marine pollution toxicity assessment. (C) 2014 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000338804700030
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/145572
专题中国科学院大连化学物理研究所
作者单位1.Dalian Univ, Chem & Environm Engn Inst, Dalian 116012, Peoples R China
2.Dalian Univ, Sch Med, Dalian 116012, Peoples R China
3.Dalian Univ, Microfluid Res Inst, Dalian 116012, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
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Zheng, Guo-xia,Li, Ya-jie,Qi, Lin-lin,et al. Marine phytoplankton motility sensor integrated into a microfluidic chip for high-throughput pollutant toxicity assessment[J]. MARINE POLLUTION BULLETIN,2014,84(1-2):147-154.
APA Zheng, Guo-xia.,Li, Ya-jie.,Qi, Lin-lin.,Liu, Xian-ming.,Wang, Hu.,...&Wang, Yun-hua.(2014).Marine phytoplankton motility sensor integrated into a microfluidic chip for high-throughput pollutant toxicity assessment.MARINE POLLUTION BULLETIN,84(1-2),147-154.
MLA Zheng, Guo-xia,et al."Marine phytoplankton motility sensor integrated into a microfluidic chip for high-throughput pollutant toxicity assessment".MARINE POLLUTION BULLETIN 84.1-2(2014):147-154.
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