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Physical Quenching in Competition with the Formation of Cyclobutane Pyrimidine Dimers in DNA Photolesion
Zhao, Hongmei; Liu, Kunhui; Song, Di; Su, Hongmei
刊名JOURNAL OF PHYSICAL CHEMISTRY A
2014-10-02
DOI10.1021/jp504944b
118期:39页:9105-9112
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Physical ; Physics, Atomic, Molecular & Chemical
研究领域[WOS]Chemistry ; Physics
关键词[WOS]ELECTRONIC GROUND-STATE ; ORBIT MATRIX-ELEMENTS ; ENERGY GAP LAW ; RADIATIONLESS TRANSITIONS ; THYMINE DIMERIZATION ; REACTION-MECHANISM ; QUANTUM YIELDS ; EXCITED-STATE ; TRIPLET-STATE ; UV
英文摘要The potential energy profiles toward formation of cyclobutane pyrimidine dimers CPD and the physical quenching after UV excitation were explored for the dinucleotide thymine dinucleoside monophosphate (TpT) using density functional theory (omega B97XD) and the time-dependent density functional theory (TD-omega B97XD). The omega B97XD functional that includes empirical dispersion correction is shown to be an appropriate method to obtain rational results for the current large reaction system of TpT. Photophysical quenching is shown to be predominant over the photochemical CPD formation. Following the initial excitation to the (1)pi pi* state, the underlying dark (1)n pi* state bifurcates the excited population to the prevailing IC to S-0 and the small ISC to the long-lived triplet state T-1 via T-4 ((3)pi pi*) state that has negligible energy gap with (1)n pi* state. Even for the reactive T1 state, two physical quenching pathways resulting in the conversion back to ground-state reactant via the T-1/S-0 crossing points are newly located, which are in strong competition with CPD formation. These results provide rationale for the recently observed nanosecond triplet decay rates in the single-stranded (dT)(18) and inefficiency of deleterious CPD formation, which allow for a deeper understanding of DNA photostability.
语种英语
WOS记录号WOS:000342651200025
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/145582
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Inst Chem, State Key Lab Mol React Dynam, BNLMS, Beijing 100190, Peoples R China
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Zhao, Hongmei,Liu, Kunhui,Song, Di,et al. Physical Quenching in Competition with the Formation of Cyclobutane Pyrimidine Dimers in DNA Photolesion[J]. JOURNAL OF PHYSICAL CHEMISTRY A,2014,118(39):9105-9112.
APA Zhao, Hongmei,Liu, Kunhui,Song, Di,&Su, Hongmei.(2014).Physical Quenching in Competition with the Formation of Cyclobutane Pyrimidine Dimers in DNA Photolesion.JOURNAL OF PHYSICAL CHEMISTRY A,118(39),9105-9112.
MLA Zhao, Hongmei,et al."Physical Quenching in Competition with the Formation of Cyclobutane Pyrimidine Dimers in DNA Photolesion".JOURNAL OF PHYSICAL CHEMISTRY A 118.39(2014):9105-9112.
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