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题名: Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics
作者: Ye, Guozhu1;  Liu, Ying2;  Yin, Peiyuan1;  Zeng, Zhongda1;  Huang, Qiang1;  Kong, Hongwei1;  Lu, Xin1;  Zhong, Laiping2;  Zhang, Zhiyuan2;  Xu, Guowang1
关键词: pseudotargeted metabolomics ;  oral squamous cell carcinoma ;  potential biomarkers ;  induction chemotherapy ;  metabolomics ;  personalized medicine
刊名: JOURNAL OF PROTEOME RESEARCH
发表日期: 2014-04-01
DOI: 10.1021/pr4011298
卷: 13, 期:4, 页:1994-2004
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemical Research Methods
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: The effect of induction chemotherapy on oral cancer is controversial owing to inconsistent results. However, the efficacy of induction chemotherapy is closely related to locoregional recurrence, distant metastasis, and overall survival after the treatment. A pseudotargeted metabolomics revealed that metabolites involved in glycolysis and amino acid metabolism were inversely regulated in patients with different before operation chemotherapy responses, and most fatty acids, steroids, and antioxidant substances were up-regulated in all patients after the treatment. Among the metabolites, lactic acid, glucose, glutamic acid, aspartic acid, leucine, and glycerol were remarkably associated with induction chemotherapy efficacy. Subsequently, lactic acid, glutamic acid, and aspartic acid were defined as potential biomarkers of the suitability and efficacy of induction chemotherapy. Our results show that 100.0 and 84.37% of patients with different chemotherapy efficacy were correctly identified in the training and test sets, respectively. Moreover, patient suitability for treatment was correctly predicted for 100.0, 81.25, and 100.0% of patients in the training, test, and external validation sets, respectively. In conclusion, metabolites related to glycolysis, redox homeostasis, and anabolic progress were indicative of induction chemotherapy efficacy both pre- and post-chemotherapy and beneficial for outcome evaluation and prediction. These results illustrate the potentials of metabolomics in personalized induction chemotherapy.
关键词[WOS]: MASS-SPECTROMETRY ;  CROSS-VALIDATION ;  BREAST-CANCER ;  STEM-CELLS ;  SERUM ;  PERFORMANCE ;  SIGNATURES ;  BIOMARKER ;  SELECTION ;  TRIAL
语种: 英语
WOS记录号: WOS:000334016400020
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145599
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Sch Med, Shanghai 200011, Peoples R China

Recommended Citation:
Ye, Guozhu,Liu, Ying,Yin, Peiyuan,et al. Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics[J]. JOURNAL OF PROTEOME RESEARCH,2014,13(4):1994-2004.
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