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Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics
Ye, Guozhu1; Liu, Ying2; Yin, Peiyuan1; Zeng, Zhongda1; Huang, Qiang1; Kong, Hongwei1; Lu, Xin1; Zhong, Laiping2; Zhang, Zhiyuan2; Xu, Guowang1
KeywordPseudotargeted Metabolomics Oral Squamous Cell Carcinoma Potential Biomarkers Induction Chemotherapy Metabolomics Personalized Medicine
Source PublicationJOURNAL OF PROTEOME RESEARCH
2014-04-01
DOI10.1021/pr4011298
Volume13Issue:4Pages:1994-2004
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemical Research Methods
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordMASS-SPECTROMETRY ; CROSS-VALIDATION ; BREAST-CANCER ; STEM-CELLS ; SERUM ; PERFORMANCE ; SIGNATURES ; BIOMARKER ; SELECTION ; TRIAL
AbstractThe effect of induction chemotherapy on oral cancer is controversial owing to inconsistent results. However, the efficacy of induction chemotherapy is closely related to locoregional recurrence, distant metastasis, and overall survival after the treatment. A pseudotargeted metabolomics revealed that metabolites involved in glycolysis and amino acid metabolism were inversely regulated in patients with different before operation chemotherapy responses, and most fatty acids, steroids, and antioxidant substances were up-regulated in all patients after the treatment. Among the metabolites, lactic acid, glucose, glutamic acid, aspartic acid, leucine, and glycerol were remarkably associated with induction chemotherapy efficacy. Subsequently, lactic acid, glutamic acid, and aspartic acid were defined as potential biomarkers of the suitability and efficacy of induction chemotherapy. Our results show that 100.0 and 84.37% of patients with different chemotherapy efficacy were correctly identified in the training and test sets, respectively. Moreover, patient suitability for treatment was correctly predicted for 100.0, 81.25, and 100.0% of patients in the training, test, and external validation sets, respectively. In conclusion, metabolites related to glycolysis, redox homeostasis, and anabolic progress were indicative of induction chemotherapy efficacy both pre- and post-chemotherapy and beneficial for outcome evaluation and prediction. These results illustrate the potentials of metabolomics in personalized induction chemotherapy.
Language英语
WOS IDWOS:000334016400020
Citation statistics
Cited Times:44[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/145599
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Sch Med, Shanghai 200011, Peoples R China
Recommended Citation
GB/T 7714
Ye, Guozhu,Liu, Ying,Yin, Peiyuan,et al. Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics[J]. JOURNAL OF PROTEOME RESEARCH,2014,13(4):1994-2004.
APA Ye, Guozhu.,Liu, Ying.,Yin, Peiyuan.,Zeng, Zhongda.,Huang, Qiang.,...&Xu, Guowang.(2014).Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics.JOURNAL OF PROTEOME RESEARCH,13(4),1994-2004.
MLA Ye, Guozhu,et al."Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics".JOURNAL OF PROTEOME RESEARCH 13.4(2014):1994-2004.
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