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题名: The effectiveness of borneol on pharmacokinetics changes of four ginsenosides in Shexiang Baoxin Pill in vivo
作者: Jiang, Peng1, 2;  Fu, Peng3;  Xiang, Li1;  Wang, Shuping1;  Liu, Xiaojun1;  Yang, Ling4;  Tao, Jianfei5;  Chen, Zhongliang2;  Zhan, Changsen2;  Huang, Ximing2;  Liu, Runhui1;  Zhang, Weidong1, 4, 6
关键词: pharmacokinetic ;  rat plasma ;  ginsenoside ;  borneol ;  Shexiang Baoxin Pill
刊名: BIOMEDICAL CHROMATOGRAPHY
发表日期: 2014-03-01
DOI: 10.1002/bmc.3037
卷: 28, 期:3, 页:419-427
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Biochemistry & Molecular Biology ;  Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry ;  Pharmacology & Pharmacy
英文摘要: Shexiang Baoxin Pill (SBP) is a traditional Chinese medicine, widely used for cardiovascular diseases in the clinic. Ginsenosides are important effective components in SBP, but their pharmacokinetic characteristics are still not known. In this paper, we studied the pharmacokinetics of ginsenoside Rb1, Rc, Re and Rg1 in SBP and investigated the effect of borneol on the pharmacokinetic characteristic of ginsenosides based on an Agilent G6410A triple quadrupole LC/MS system. Results showed that the pharmacokinetic parameters of ginsenoside Rb1, Rc, Re and Rg1 in rat plasma after oral administration of SBP are significantly different with oral administration of SBP without Borneolum Syntheticum. Plasma pharmacokinetic profiles after oral administration of ginsenoside Rb1, Rc, Re, Rg1 and co-administration with borneol at three different ratios (10:1, 1:1 and 1:10 ginsenoside vs borneol, w/w) were also determined. It was demonstrated that borneol can elevate the plasma concentration of ginsenosides after co-admininstration. Copyright (c) 2013 John Wiley & Sons, Ltd.
关键词[WOS]: TANDEM MASS-SPECTROMETRY ;  PANAX-NOTOGINSENG ;  RAT PLASMA ;  MYOCARDIAL-INFARCTION ;  GINSENG SAPONINS ;  ABSORPTION ;  RB-1 ;  METABOLISM ;  EXCRETION ;  RG(1)
语种: 英语
WOS记录号: WOS:000330839500016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145611
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China
2.Shanghai Hutchison Pharmaceut Co, Shanghai 200331, Peoples R China
3.Second Mil Med Univ, Changhai Hosp, Dept Pharm, Shanghai 200433, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
5.Shanghai Yangsi Hosipital, Dept Pharm, Shanghai 200126, Peoples R China
6.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China

Recommended Citation:
Jiang, Peng,Fu, Peng,Xiang, Li,et al. The effectiveness of borneol on pharmacokinetics changes of four ginsenosides in Shexiang Baoxin Pill in vivo[J]. BIOMEDICAL CHROMATOGRAPHY,2014,28(3):419-427.
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