DICP OpenIR
The effectiveness of borneol on pharmacokinetics changes of four ginsenosides in Shexiang Baoxin Pill in vivo
Jiang, Peng1,2; Fu, Peng3; Xiang, Li1; Wang, Shuping1; Liu, Xiaojun1; Yang, Ling4; Tao, Jianfei5; Chen, Zhongliang2; Zhan, Changsen2; Huang, Ximing2; Liu, Runhui1; Zhang, Weidong1,4,6
KeywordPharmacokinetic Rat Plasma Ginsenoside Borneol Shexiang Baoxin Pill
Source PublicationBIOMEDICAL CHROMATOGRAPHY
2014-03-01
DOI10.1002/bmc.3037
Volume28Issue:3Pages:419-427
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
WOS KeywordTANDEM MASS-SPECTROMETRY ; PANAX-NOTOGINSENG ; RAT PLASMA ; MYOCARDIAL-INFARCTION ; GINSENG SAPONINS ; ABSORPTION ; RB-1 ; METABOLISM ; EXCRETION ; RG(1)
AbstractShexiang Baoxin Pill (SBP) is a traditional Chinese medicine, widely used for cardiovascular diseases in the clinic. Ginsenosides are important effective components in SBP, but their pharmacokinetic characteristics are still not known. In this paper, we studied the pharmacokinetics of ginsenoside Rb1, Rc, Re and Rg1 in SBP and investigated the effect of borneol on the pharmacokinetic characteristic of ginsenosides based on an Agilent G6410A triple quadrupole LC/MS system. Results showed that the pharmacokinetic parameters of ginsenoside Rb1, Rc, Re and Rg1 in rat plasma after oral administration of SBP are significantly different with oral administration of SBP without Borneolum Syntheticum. Plasma pharmacokinetic profiles after oral administration of ginsenoside Rb1, Rc, Re, Rg1 and co-administration with borneol at three different ratios (10:1, 1:1 and 1:10 ginsenoside vs borneol, w/w) were also determined. It was demonstrated that borneol can elevate the plasma concentration of ginsenosides after co-admininstration. Copyright (c) 2013 John Wiley & Sons, Ltd.
Language英语
WOS IDWOS:000330839500016
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/145611
Collection中国科学院大连化学物理研究所
Affiliation1.Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China
2.Shanghai Hutchison Pharmaceut Co, Shanghai 200331, Peoples R China
3.Second Mil Med Univ, Changhai Hosp, Dept Pharm, Shanghai 200433, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
5.Shanghai Yangsi Hosipital, Dept Pharm, Shanghai 200126, Peoples R China
6.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Peng,Fu, Peng,Xiang, Li,et al. The effectiveness of borneol on pharmacokinetics changes of four ginsenosides in Shexiang Baoxin Pill in vivo[J]. BIOMEDICAL CHROMATOGRAPHY,2014,28(3):419-427.
APA Jiang, Peng.,Fu, Peng.,Xiang, Li.,Wang, Shuping.,Liu, Xiaojun.,...&Zhang, Weidong.(2014).The effectiveness of borneol on pharmacokinetics changes of four ginsenosides in Shexiang Baoxin Pill in vivo.BIOMEDICAL CHROMATOGRAPHY,28(3),419-427.
MLA Jiang, Peng,et al."The effectiveness of borneol on pharmacokinetics changes of four ginsenosides in Shexiang Baoxin Pill in vivo".BIOMEDICAL CHROMATOGRAPHY 28.3(2014):419-427.
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