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题名: Mulberroside a protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion
作者: Wang, Cai-Ping1;  Zhang, Lu-Zhong1;  Li, Gui-Cai1;  Shi, Yun-wei1;  Li, Jian-Long1;  Zhang, Xiao-Chuan1;  Wang, Zhi-Wei1, 2;  Ding, Fei1;  Liang, Xin-Miao1, 3
关键词: apoptosis ;  mulberroside A ;  inflammation ;  ischemia ;  neuroprotection
刊名: JOURNAL OF NEUROSCIENCE RESEARCH
发表日期: 2014-07-01
DOI: 10.1002/jnr.23374
卷: 92, 期:7, 页:944-954
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
英文摘要: Mulberroside A is a natural polyhydroxylated stilbene compound present at relatively high abundance in the roots and twigs of Morus alba L. It is known for its nephroprotective, hypoglycemic, and antidiabetic effects. Because its metabolite, oxyresveratrol, possessed purported anti-inflammatory and neuroprotective effects, we proposed that mulberroside A may elicit neuroprotective effects that can be used in the treatment of brain ischemic injury. Therefore, we decided to investigate the pharmacological properties of mulberroside A in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion (OGD/R), evaluating its ability to counteract the hypoxia-ischemia impairment. The results showed that mulberroside A elicited neuroprotective effects comparable to nimodipine. The mechanistic studies showed that mulberroside A decreased the expressions of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta, and IL-6 and inhibited the activation of NALP3, caspase-1, and nuclear factor-kappa B and the phosphorylation of extracellular signal-regulated protein kinases, the c-Jun N-terminal kinase, and p38, exhibiting anti-inflammatory antiapoptotic effects. Our results also further demonstrate that the proinflammatory cytokines of IL-1 beta, IL-6, and TNF-alpha are promising targets for treatment of cerebral ischemic injury. Although further investigation is required for its development, all of these findings led us to speculate that mulberroside A is a candidate for the treatment of ischemic stroke, which would act as a multifactorial neuroprotectant. (c) 2014 Wiley Periodicals, Inc.
关键词[WOS]: MORUS-ALBA L. ;  FOCAL CEREBRAL-ISCHEMIA ;  CELL-DEATH ;  IN-VITRO ;  BRAIN-INJURY ;  OXIDATIVE STRESS ;  OXYRESVERATROL ;  ACTIVATION ;  STROKE ;  PATHWAYS
语种: 英语
WOS记录号: WOS:000335704400013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145642
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Peoples R China
2.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Wang, Cai-Ping,Zhang, Lu-Zhong,Li, Gui-Cai,et al. Mulberroside a protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2014,92(7):944-954.
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