DICP OpenIR
Mulberroside a protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion
Wang, Cai-Ping1; Zhang, Lu-Zhong1; Li, Gui-Cai1; Shi, Yun-wei1; Li, Jian-Long1; Zhang, Xiao-Chuan1; Wang, Zhi-Wei1,2; Ding, Fei1; Liang, Xin-Miao1,3
KeywordApoptosis Mulberroside a Inflammation Ischemia Neuroprotection
Source PublicationJOURNAL OF NEUROSCIENCE RESEARCH
2014-07-01
DOI10.1002/jnr.23374
Volume92Issue:7Pages:944-954
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectNeurosciences
WOS Research AreaNeurosciences & Neurology
WOS KeywordMORUS-ALBA L. ; FOCAL CEREBRAL-ISCHEMIA ; CELL-DEATH ; IN-VITRO ; BRAIN-INJURY ; OXIDATIVE STRESS ; OXYRESVERATROL ; ACTIVATION ; STROKE ; PATHWAYS
AbstractMulberroside A is a natural polyhydroxylated stilbene compound present at relatively high abundance in the roots and twigs of Morus alba L. It is known for its nephroprotective, hypoglycemic, and antidiabetic effects. Because its metabolite, oxyresveratrol, possessed purported anti-inflammatory and neuroprotective effects, we proposed that mulberroside A may elicit neuroprotective effects that can be used in the treatment of brain ischemic injury. Therefore, we decided to investigate the pharmacological properties of mulberroside A in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion (OGD/R), evaluating its ability to counteract the hypoxia-ischemia impairment. The results showed that mulberroside A elicited neuroprotective effects comparable to nimodipine. The mechanistic studies showed that mulberroside A decreased the expressions of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta, and IL-6 and inhibited the activation of NALP3, caspase-1, and nuclear factor-kappa B and the phosphorylation of extracellular signal-regulated protein kinases, the c-Jun N-terminal kinase, and p38, exhibiting anti-inflammatory antiapoptotic effects. Our results also further demonstrate that the proinflammatory cytokines of IL-1 beta, IL-6, and TNF-alpha are promising targets for treatment of cerebral ischemic injury. Although further investigation is required for its development, all of these findings led us to speculate that mulberroside A is a candidate for the treatment of ischemic stroke, which would act as a multifactorial neuroprotectant. (c) 2014 Wiley Periodicals, Inc.
Language英语
WOS IDWOS:000335704400013
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/145642
Collection中国科学院大连化学物理研究所
Affiliation1.Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Peoples R China
2.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Wang, Cai-Ping,Zhang, Lu-Zhong,Li, Gui-Cai,et al. Mulberroside a protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2014,92(7):944-954.
APA Wang, Cai-Ping.,Zhang, Lu-Zhong.,Li, Gui-Cai.,Shi, Yun-wei.,Li, Jian-Long.,...&Liang, Xin-Miao.(2014).Mulberroside a protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion.JOURNAL OF NEUROSCIENCE RESEARCH,92(7),944-954.
MLA Wang, Cai-Ping,et al."Mulberroside a protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion".JOURNAL OF NEUROSCIENCE RESEARCH 92.7(2014):944-954.
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