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题名: Systems pharmacology in drug discovery and therapeutic insight for herbal medicines
作者: Huang, Chao1;  Zheng, Chunli2;  Li, Yan3;  Wang, Yonghua1;  Lu, Aiping4;  Yang, Ling5
关键词: systems pharmacology ;  herbal medicines ;  ADME ;  network pharmacology ;  depression
刊名: BRIEFINGS IN BIOINFORMATICS
发表日期: 2014-09-01
DOI: 10.1093/bib/bbt035
卷: 15, 期:5, 页:710-733
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemical Research Methods ;  Mathematical & Computational Biology
研究领域[WOS]: Biochemistry & Molecular Biology ;  Mathematical & Computational Biology
英文摘要: Systems pharmacology is an emerging field that integrates systems biology and pharmacology to advance the process of drug discovery, development and the understanding of therapeutic mechanisms. The aim of the present work is to highlight the role that the systems pharmacology plays across the traditional herbal medicines discipline, which is exemplified by a case study of botanical drugs applied in the treatment of depression. First, based on critically examined pharmacology and clinical knowledge, we propose a large-scale statistical analysis to evaluate the efficiency of herbs used in traditional medicines. Second, we focus on the exploration of the active ingredients and targets by carrying out complex structure-, omics- and network-based systematic investigations. Third, specific informatics methods are developed to infer drug-disease connections, with purpose to understand how drugs work on the specific targets and pathways. Finally, we propose a new systems pharmacology method, which is further applied to an integrated platform (Herbal medicine Systems Pharmacology) of blended herbal medicine and omics data sets, allowing for the systematization of current and traditional knowledge of herbal medicines and, importantly, for the application of this emerging body of knowledge to the development of new drugs for complex human diseases.
关键词[WOS]: MOLECULAR INTERACTION DATABASE ;  PROTEIN INTERACTION DATABASE ;  IN-SILICO ;  MAJOR DEPRESSION ;  CARDIOVASCULAR-DISEASE ;  GLUTAMATERGIC SYNAPSES ;  SELECTIVE INHIBITORS ;  INTERACTION NETWORK ;  ORGANIC-COMPOUNDS ;  ADME PROPERTIES
语种: 英语
WOS记录号: WOS:000342911900004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145661
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Northwest A&F Univ, Coll Life Sci, Ctr Bioinformat, Yang Ling 712100, Shaanxi, Peoples R China
2.Northwest Univ, Coll Life Sci, Xian, Shaanxi, Peoples R China
3.Dalian Univ Technol, Dept Mat Sci & Chem Engn, Dalian, Liaoning, Peoples R China
4.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Liaoning, Peoples R China

Recommended Citation:
Huang, Chao,Zheng, Chunli,Li, Yan,et al. Systems pharmacology in drug discovery and therapeutic insight for herbal medicines[J]. BRIEFINGS IN BIOINFORMATICS,2014,15(5):710-733.
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