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题名: Glucuronidation of aurantio-obtusin: identification of human UDP-glucuronosyltransferases and species differences
作者: Mi, Bao-Li1;  Sun, Qi2;  Qu, Yan-Qing3;  Gao, Xiao-Xu1;  Yu, Zhen-Wen1;  Ge, Guang-Bo4;  Cai, Shan-Shan1;  Zhang, Jie1;  Zheng, Yan-Chao1;  Zhang, Zhen-Qiu1
关键词: Aurantio-obtusin ;  species difference ;  UDP-glucuronosyltransferase (UGT)
刊名: XENOBIOTICA
发表日期: 2014-08-01
DOI: 10.3109/00498254.2014.895881
卷: 44, 期:8, 页:716-721
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy ;  Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ;  Toxicology
英文摘要: 1. The aurantio-obtusin's glucuronide was detected when aurantio-obtusin was incubated with human liver microsomes (HLMs). Recombinant UGT isoforms screening experiment showed that UGT1A8 was the major isoform contributed to the glucuronidation.
关键词[WOS]: METABOLISM ;  BIOAVAILABILITY ;  ELUCIDATION
语种: 英语
WOS记录号: WOS:000339564100005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145663
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Liaoning Univ Tradit Chinese Med, Pharmaceut Coll, Dalian 116600, Peoples R China
2.JiLin Aodong Med Ind Grp Co Ltd, Dept Res & Dev, Dunhua, Peoples R China
3.Yantaishan Hosp, Yantai, Shandong, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China

Recommended Citation:
Mi, Bao-Li,Sun, Qi,Qu, Yan-Qing,et al. Glucuronidation of aurantio-obtusin: identification of human UDP-glucuronosyltransferases and species differences[J]. XENOBIOTICA,2014,44(8):716-721.
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