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Glucuronidation of aurantio-obtusin: identification of human UDP-glucuronosyltransferases and species differences
Mi, Bao-Li1; Sun, Qi2; Qu, Yan-Qing3; Gao, Xiao-Xu1; Yu, Zhen-Wen1; Ge, Guang-Bo4; Cai, Shan-Shan1; Zhang, Jie1; Zheng, Yan-Chao1; Zhang, Zhen-Qiu1
关键词Aurantio-obtusin Species Difference Udp-glucuronosyltransferase (Ugt)
刊名XENOBIOTICA
2014-08-01
DOI10.3109/00498254.2014.895881
44期:8页:716-721
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]METABOLISM ; BIOAVAILABILITY ; ELUCIDATION
英文摘要1. The aurantio-obtusin's glucuronide was detected when aurantio-obtusin was incubated with human liver microsomes (HLMs). Recombinant UGT isoforms screening experiment showed that UGT1A8 was the major isoform contributed to the glucuronidation.
语种英语
WOS记录号WOS:000339564100005
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/145663
专题中国科学院大连化学物理研究所
作者单位1.Liaoning Univ Tradit Chinese Med, Pharmaceut Coll, Dalian 116600, Peoples R China
2.JiLin Aodong Med Ind Grp Co Ltd, Dept Res & Dev, Dunhua, Peoples R China
3.Yantaishan Hosp, Yantai, Shandong, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China
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GB/T 7714
Mi, Bao-Li,Sun, Qi,Qu, Yan-Qing,et al. Glucuronidation of aurantio-obtusin: identification of human UDP-glucuronosyltransferases and species differences[J]. XENOBIOTICA,2014,44(8):716-721.
APA Mi, Bao-Li.,Sun, Qi.,Qu, Yan-Qing.,Gao, Xiao-Xu.,Yu, Zhen-Wen.,...&Zhang, Zhen-Qiu.(2014).Glucuronidation of aurantio-obtusin: identification of human UDP-glucuronosyltransferases and species differences.XENOBIOTICA,44(8),716-721.
MLA Mi, Bao-Li,et al."Glucuronidation of aurantio-obtusin: identification of human UDP-glucuronosyltransferases and species differences".XENOBIOTICA 44.8(2014):716-721.
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