中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146
作者: Wagner, Robert1, 2, 3;  Li, Jia4;  Kenar, Erhan5, 6;  Kohlbacher, Oliver5, 6;  Machicao, Fausto1, 2, 3;  Haering, Hans-Ulrich1, 2, 3;  Fritsche, Andreas1, 2, 3;  Xu, Guowang4;  Lehmann, Rainer2, 3, 7
刊名: SCIENTIFIC REPORTS
发表日期: 2014-06-13
DOI: 10.1038/srep05296
卷: 4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: An important role of the type 2 diabetes risk variant rs7903146 in TCF7L2 in metabolic actions of various tissues, in particular of the liver, has recently been demonstrated by functional animal studies. Accordingly, the TT diabetes risk allele may lead to currently unknown alterations in human. Our study revealed no differences in the kinetics of glucose, insulin, C-peptide and non-esterified fatty acids during an OGTT in homozygous participants from a German diabetes risk cohort (n = 1832) carrying either the rs7903146 CC (n = 15) or the TT (n = 15) genotype. However, beta-cell function was impaired for TT carriers. Covering more than 4000 metabolite ions the plasma metabolome did not reveal any differences between genotypes. Our study argues against a relevant impact of TCF7L2 rs7903146 on the systemic level in humans, but confirms the role in the pathogenesis of type 2 diabetes in humans as a mechanism impairing insulin secretion.
关键词[WOS]: DIABETES RISK GENES ;  INSULIN-SECRETION ;  GLUCOSE-METABOLISM ;  ISLET FUNCTION ;  TCF7L2 ;  POLYMORPHISMS ;  MECHANISMS ;  PREVENTION ;  MORPHOLOGY ;  IMPACT
语种: 英语
WOS记录号: WOS:000337340500002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145672
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Univ Hosp Tuebingen, Dept Internal Med 4, Div Endocrinol Diabetol Angiol & Nephrol, Tubingen, Germany
2.Univ Tubingen, Helmholtz Zentrum Munchen, Inst Diabet Res & Metabol Dis, Tubingen, Germany
3.German Ctr Diabet Res DZD, Tubingen, Germany
4.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
5.Univ Tubingen, Quantitat Biol Ctr, Ctr Bioinformat, D-72076 Tubingen, Germany
6.Univ Tubingen, Dept Comp Sci, D-72076 Tubingen, Germany
7.Univ Hosp Tuebingen, Dept Internal Med, Div Clin Chem & Pathobiochem, Tubingen, Germany

Recommended Citation:
Wagner, Robert,Li, Jia,Kenar, Erhan,et al. Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146[J]. SCIENTIFIC REPORTS,2014,4.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Wagner, Robert]'s Articles
 [Li, Jia]'s Articles
 [Kenar, Erhan]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Wagner, Robert]‘s Articles
 [Li, Jia]‘s Articles
 [Kenar, Erhan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace