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题名: Effect of Lipolysis on Drug Release from Self-microemulsifying Drug Delivery Systems (SMEDDS) with Different Core/Shell Drug Location
作者: Zhang, Jianbin1, 2;  Lv, Yan1, 2;  Zhao, Shan1, 2;  Wang, Bing1, 2;  Tan, Mingqian1;  Xie, Hongguo1;  Lv, Guojun1;  Ma, Xiaojun1
关键词: core/shell location ;  drug release ;  fluorescence spectra ;  lipolysis ;  self-microemulsifying drug delivery system (SMEDDS)
刊名: AAPS PHARMSCITECH
发表日期: 2014-06-01
DOI: 10.1208/s12249-014-0096-9
卷: 15, 期:3, 页:731-740
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: The objective of this study is to investigate the effect of lipolysis on the release of poorly water-soluble drug from SMEDDS in the perspective of drug core/shell location. For this purpose, four SMEDDS formulations with various core/shell properties were developed based on long-chain lipid or medium-chain lipid as well as different surfactant/oil ratios. Poorly water-soluble drugs, hymecromone and resveratrol, were significantly solubilized in all SMEDDS formulations and the diluted microemulsions. Fluorescence spectra analysis indicated that hymecromone was mainly located in the shell of microemulsions, while resveratrol was located in the core. The effect of lipolysis on the release rates of drugs with different core/shell locations were investigated by a modified in vitro drug release model. For the drug located in the shell, hymecromone, the release profiles were not affected during the lipolysis process and no significant differences were observed among four formulations. For the drug located in the core, resveratrol, the release rates were increased to various degrees depending on the extent of digestion. In conclusion, the drug core/shell location plays an important role for determining the effect of lipolysis on drug release from SMEDDS formulation.
关键词[WOS]: WATER-SOLUBLE DRUGS ;  IN-VITRO DIGESTION ;  X-RAY-SCATTERING ;  MEDIUM-CHAIN ;  ORAL BIOAVAILABILITY ;  PHASE-BEHAVIOR ;  FORMULATION ;  DISSOLUTION ;  ABSORPTION ;  LONG
语种: 英语
WOS记录号: WOS:000336729800019
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145687
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China

Recommended Citation:
Zhang, Jianbin,Lv, Yan,Zhao, Shan,et al. Effect of Lipolysis on Drug Release from Self-microemulsifying Drug Delivery Systems (SMEDDS) with Different Core/Shell Drug Location[J]. AAPS PHARMSCITECH,2014,15(3):731-740.
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