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Carbon Quantum Dot Stabilized Gadolinium Nanoprobe Prepared via a One-Pot Hydrothermal Approach for Magnetic Resonance and Fluorescence Dual-Modality Bioimaging
Xu, Yang1,2; Jia, Xiao-Hua3; Yin, Xue-Bo1,2; He, Xi-Wen1,2; Zhang, Yu-Kui1,2,4
刊名ANALYTICAL CHEMISTRY
2014-12-16
DOI10.1021/ac503002c
86期:24页:12122-12129
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]IMAGING CONTRAST AGENTS ; IN-VIVO ; SILICA NANOPARTICLES ; DRUG-DELIVERY ; NANOTUBES ; ZEBRAFISH ; BIODISTRIBUTION ; NANOTECHNOLOGY ; GLYCANS ; CANCER
英文摘要Magnetic resonance imaging (MRI) is used extensively for clinical diagnoses. It is critical to design and develop highly efficient MR contrast agents with simple preparation procedure, low toxicity, and high biocompatibility. Here, we report a carbon quantum dots (CQDs)-stabilized gadolinium hybrid nanoprobe (Gd-CQDs) prepared via a one-pot hydrothermal treatment of the mixture of citrate acid, ethanediamine, and GdCl3 at 200 degrees C for 4 h. In vitro and in vivo tests confirmed their low toxicity and high biocompatibility. Gd-CQDs were observed to have a higher MR response than gadopentetic acid dimeglumine (Gd-DTPA) because of their high Gd content and hydrophilicity. Moreover, the fluorescence of CQDs was remained in Gd-CQDs. The in vivo MR and fluorescence dual-modality imaging of Gd-CQDs was confirmed with zebrafish embryo and mice as models. The modification of Gd-CQDs with arginine-glycine-aspartic acid (RGD) tripeptide provided a high affinity to U87 cancer cells for targeted imaging. Whereas the MR response showed a depth penetration and spatial visualization, fluorescence revealed the fine distribution of Gd-CQDs in tissues because of its high resolution and sensitivity. We found that Gd-CQDs distributed in the tissues in a heterogeneous mode: they entered into the tissue cells but were observed less in the extracellular matrix. The MR and fluorescence dual-modality imaging of Gd-CQDs makes them a potential contrast agent for clinic applications because of their simple preparation procedure, ease of functionalization, high contrast efficiency, low toxicity, and high biocompatibility.
语种英语
WOS记录号WOS:000346683900031
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/145692
专题中国科学院大连化学物理研究所
作者单位1.Nankai Univ, Coll Chem, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Nankai Univ, Coll Chem, Res Ctr Analyt Sci, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
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Xu, Yang,Jia, Xiao-Hua,Yin, Xue-Bo,et al. Carbon Quantum Dot Stabilized Gadolinium Nanoprobe Prepared via a One-Pot Hydrothermal Approach for Magnetic Resonance and Fluorescence Dual-Modality Bioimaging[J]. ANALYTICAL CHEMISTRY,2014,86(24):12122-12129.
APA Xu, Yang,Jia, Xiao-Hua,Yin, Xue-Bo,He, Xi-Wen,&Zhang, Yu-Kui.(2014).Carbon Quantum Dot Stabilized Gadolinium Nanoprobe Prepared via a One-Pot Hydrothermal Approach for Magnetic Resonance and Fluorescence Dual-Modality Bioimaging.ANALYTICAL CHEMISTRY,86(24),12122-12129.
MLA Xu, Yang,et al."Carbon Quantum Dot Stabilized Gadolinium Nanoprobe Prepared via a One-Pot Hydrothermal Approach for Magnetic Resonance and Fluorescence Dual-Modality Bioimaging".ANALYTICAL CHEMISTRY 86.24(2014):12122-12129.
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