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题名: Improving Stability and Biocompatibility of Alginate/Chitosan Microcapsule by Fabricating Bi-Functional Membrane
作者: Zheng, Guoshuang1, 3;  Liu, Xiudong2;  Wang, Xiuli1;  Chen, Li1, 3;  Xie, Hongguo1;  Wang, Feng4;  Zheng, Huizhen1, 3;  Yu, Weiting1;  Ma, Xiaojun1
关键词: alginate/chitosan microcapsules ;  bi-functional membranes ;  biocompatibility mechanical strength ;  surface roughness
刊名: MACROMOLECULAR BIOSCIENCE
发表日期: 2014-05-01
DOI: 10.1002/mabi.201300474
卷: 14, 期:5, 页:655-666
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Technology ;  Physical Sciences
类目[WOS]: Biochemistry & Molecular Biology ;  Materials Science, Biomaterials ;  Polymer Science
研究领域[WOS]: Biochemistry & Molecular Biology ;  Materials Science ;  Polymer Science
英文摘要: Cell encapsulation technology holds promise for the cell-based therapy. But poor mechanical strength and biocompatibility of microcapsule membrane are still obstacles for the clinical applications. A novel strategy is presented to prepare AC(1)C(2)A microcapsules with bifunctional membrane (that is, both desirable biocompatibility and membrane stability) by sequentially complexing chitosans with higher deacetylation degree (C-1) and lower deacetylation degree (C-2) on alginate (A) gel beads. Both in vitro and in vivo evaluation of AC(1)C(2)A microcapsules demonstrate higher membrane stability and less cell adhesion, because the introduction of C-2 increases membrane strength and decreases surface roughness. Moreover, diffusion test of AC(1)C(2)A microcapsules displays no inward permeation of IgG protein suggesting good immunoisolation function. The results demonstrate that AC(1)C(2)A microcapsules with bi-functional membrane could be a promising candidate for microencapsulated cell implantation with cost effective usage of naturally biocompatible polysaccharides.
关键词[WOS]: ALGINATE-CHITOSAN MICROCAPSULES ;  PROTEIN ADSORPTION ;  HYDROGEL MICROCAPSULES ;  CELL ENCAPSULATION ;  IN-VITRO ;  CAPSULES ;  IMMUNOISOLATION ;  TECHNOLOGY ;  POLYCATION ;  RESISTANCE
语种: 英语
WOS记录号: WOS:000336244100006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145693
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Dalian Univ, Coll Environm & Chem Engn, Dalian Econ Technol Dev Zone, Dalian 116622, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Opt Fabricat & Coating, Dalian 116023, Peoples R China

Recommended Citation:
Zheng, Guoshuang,Liu, Xiudong,Wang, Xiuli,et al. Improving Stability and Biocompatibility of Alginate/Chitosan Microcapsule by Fabricating Bi-Functional Membrane[J]. MACROMOLECULAR BIOSCIENCE,2014,14(5):655-666.
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