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Explicit Differentiation of G-Quadruplex/Ligand Interactions: Triplet Excited States as Sensitive Reporters
Song, Di; Yang, Wen; Qin, Tingxiao; Wu, Lidan; Liu, Kunhui; Su, Hongmei
Source PublicationJOURNAL OF PHYSICAL CHEMISTRY LETTERS
2014-07-03
DOI10.1021/jz501040a
Volume5Issue:13Pages:2259-2266
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
WOS SubjectChemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Atomic, Molecular & Chemical
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS KeywordCATIONIC PORPHYRINS ; SMALL-MOLECULE ; GUANINE NANOSTRUCTURES ; CIRCULAR-DICHROISM ; OPTICAL-PROPERTIES ; NUCLEIC-ACIDS ; DNA ; BINDING ; SPECTROSCOPY ; CONFORMATION
AbstractWe report a new transient spectral method utilizing triplet excited state as sensitive reporters to monitor and differentiate the multiplex G-quadruplex/ligand interactions in a single assay, which is a difficult task and usually requires a combination of several techniques. From a systematic study on the interactions of porphyrin (TMPyP4) with each telomeric G-quadruplex: AG(3)(T(2)AG(3))(3), G(2)T(2)G(2)TGTG(2)T(2)G(2), (G(4)T(4)G(4))(2), and (TG(4)T)(4), it is convincingly shown that the ligand triplet decay lifetimes are sensitive to the local bound microenviromnent within G-quadruplexes, from which the coexisting binding modes of end-stacking, intercalation, and sandwich are distinguished and their respective contribution are determined. The complete scenario of mixed interaction modes is thus revealed, shedding light on the past controversial issues. Additional control experiments demonstrate the sensitivity of this triplet reporter method, which can even capture the binding behavior change as the G-quadruplex structures are adjusted by Na+ or K+.
Language英语
WOS IDWOS:000338693200016
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/145696
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Inst Chem, State Key Lab Mol React Dynam, BNLMS, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Song, Di,Yang, Wen,Qin, Tingxiao,et al. Explicit Differentiation of G-Quadruplex/Ligand Interactions: Triplet Excited States as Sensitive Reporters[J]. JOURNAL OF PHYSICAL CHEMISTRY LETTERS,2014,5(13):2259-2266.
APA Song, Di,Yang, Wen,Qin, Tingxiao,Wu, Lidan,Liu, Kunhui,&Su, Hongmei.(2014).Explicit Differentiation of G-Quadruplex/Ligand Interactions: Triplet Excited States as Sensitive Reporters.JOURNAL OF PHYSICAL CHEMISTRY LETTERS,5(13),2259-2266.
MLA Song, Di,et al."Explicit Differentiation of G-Quadruplex/Ligand Interactions: Triplet Excited States as Sensitive Reporters".JOURNAL OF PHYSICAL CHEMISTRY LETTERS 5.13(2014):2259-2266.
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