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Explicit Differentiation of G-Quadruplex/Ligand Interactions: Triplet Excited States as Sensitive Reporters
Song, Di; Yang, Wen; Qin, Tingxiao; Wu, Lidan; Liu, Kunhui; Su, Hongmei
刊名JOURNAL OF PHYSICAL CHEMISTRY LETTERS
2014-07-03
DOI10.1021/jz501040a
5期:13页:2259-2266
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
类目[WOS]Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Atomic, Molecular & Chemical
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]CATIONIC PORPHYRINS ; SMALL-MOLECULE ; GUANINE NANOSTRUCTURES ; CIRCULAR-DICHROISM ; OPTICAL-PROPERTIES ; NUCLEIC-ACIDS ; DNA ; BINDING ; SPECTROSCOPY ; CONFORMATION
英文摘要We report a new transient spectral method utilizing triplet excited state as sensitive reporters to monitor and differentiate the multiplex G-quadruplex/ligand interactions in a single assay, which is a difficult task and usually requires a combination of several techniques. From a systematic study on the interactions of porphyrin (TMPyP4) with each telomeric G-quadruplex: AG(3)(T(2)AG(3))(3), G(2)T(2)G(2)TGTG(2)T(2)G(2), (G(4)T(4)G(4))(2), and (TG(4)T)(4), it is convincingly shown that the ligand triplet decay lifetimes are sensitive to the local bound microenviromnent within G-quadruplexes, from which the coexisting binding modes of end-stacking, intercalation, and sandwich are distinguished and their respective contribution are determined. The complete scenario of mixed interaction modes is thus revealed, shedding light on the past controversial issues. Additional control experiments demonstrate the sensitivity of this triplet reporter method, which can even capture the binding behavior change as the G-quadruplex structures are adjusted by Na+ or K+.
语种英语
WOS记录号WOS:000338693200016
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/145696
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Inst Chem, State Key Lab Mol React Dynam, BNLMS, Beijing 100190, Peoples R China
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GB/T 7714
Song, Di,Yang, Wen,Qin, Tingxiao,et al. Explicit Differentiation of G-Quadruplex/Ligand Interactions: Triplet Excited States as Sensitive Reporters[J]. JOURNAL OF PHYSICAL CHEMISTRY LETTERS,2014,5(13):2259-2266.
APA Song, Di,Yang, Wen,Qin, Tingxiao,Wu, Lidan,Liu, Kunhui,&Su, Hongmei.(2014).Explicit Differentiation of G-Quadruplex/Ligand Interactions: Triplet Excited States as Sensitive Reporters.JOURNAL OF PHYSICAL CHEMISTRY LETTERS,5(13),2259-2266.
MLA Song, Di,et al."Explicit Differentiation of G-Quadruplex/Ligand Interactions: Triplet Excited States as Sensitive Reporters".JOURNAL OF PHYSICAL CHEMISTRY LETTERS 5.13(2014):2259-2266.
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