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题名: Explicit Differentiation of G-Quadruplex/Ligand Interactions: Triplet Excited States as Sensitive Reporters
作者: Song, Di1;  Yang, Wen1;  Qin, Tingxiao1;  Wu, Lidan1;  Liu, Kunhui1;  Su, Hongmei1
刊名: JOURNAL OF PHYSICAL CHEMISTRY LETTERS
发表日期: 2014-07-03
DOI: 10.1021/jz501040a
卷: 5, 期:13, 页:2259-2266
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Physical ;  Nanoscience & Nanotechnology ;  Materials Science, Multidisciplinary ;  Physics, Atomic, Molecular & Chemical
研究领域[WOS]: Chemistry ;  Science & Technology - Other Topics ;  Materials Science ;  Physics
英文摘要: We report a new transient spectral method utilizing triplet excited state as sensitive reporters to monitor and differentiate the multiplex G-quadruplex/ligand interactions in a single assay, which is a difficult task and usually requires a combination of several techniques. From a systematic study on the interactions of porphyrin (TMPyP4) with each telomeric G-quadruplex: AG(3)(T(2)AG(3))(3), G(2)T(2)G(2)TGTG(2)T(2)G(2), (G(4)T(4)G(4))(2), and (TG(4)T)(4), it is convincingly shown that the ligand triplet decay lifetimes are sensitive to the local bound microenviromnent within G-quadruplexes, from which the coexisting binding modes of end-stacking, intercalation, and sandwich are distinguished and their respective contribution are determined. The complete scenario of mixed interaction modes is thus revealed, shedding light on the past controversial issues. Additional control experiments demonstrate the sensitivity of this triplet reporter method, which can even capture the binding behavior change as the G-quadruplex structures are adjusted by Na+ or K+.
关键词[WOS]: CATIONIC PORPHYRINS ;  SMALL-MOLECULE ;  GUANINE NANOSTRUCTURES ;  CIRCULAR-DICHROISM ;  OPTICAL-PROPERTIES ;  NUCLEIC-ACIDS ;  DNA ;  BINDING ;  SPECTROSCOPY ;  CONFORMATION
语种: 英语
WOS记录号: WOS:000338693200016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145696
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, State Key Lab Mol React Dynam, BNLMS, Beijing 100190, Peoples R China

Recommended Citation:
Song, Di,Yang, Wen,Qin, Tingxiao,et al. Explicit Differentiation of G-Quadruplex/Ligand Interactions: Triplet Excited States as Sensitive Reporters[J]. JOURNAL OF PHYSICAL CHEMISTRY LETTERS,2014,5(13):2259-2266.
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