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题名: In vivo detection of magnetic labeled oxidized multi-walled carbon nanotubes by magnetic resonance imaging
作者: Li, Ruibin1;  Wu, Ren'an2;  Zhao, Liang2;  Qin, Hongqiang2;  Wu, Jianlin3;  Zhang, Jingwen4;  Bao, Ruyi4;  Zou, Hanfa2
关键词: carbon nanotubes ;  biodistribution ;  magnetic resonance imaging ;  toxicity ;  rat
刊名: NANOTECHNOLOGY
发表日期: 2014-12-12
DOI: 10.1088/0957-4484/25/49/495102
卷: 25, 期:49
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology ;  Physical Sciences
类目[WOS]: Nanoscience & Nanotechnology ;  Materials Science, Multidisciplinary ;  Physics, Applied
研究领域[WOS]: Science & Technology - Other Topics ;  Materials Science ;  Physics
英文摘要: Functionalized carbon nanotubes (f-CNTs) have been widely used in bio-medicine as drug carriers, bio-sensors, imaging agents and tissue engineering additives, which demands better understanding of their in vivo behavior because of the increasing exposure potential to humans. However, there are limited studies to investigate the in vivo biodistribution and elimination of f-CNTs. In this study, superparamagnetic iron oxides (SPIOs) were used to label oxidized multiwalled carbon nanotubes (o-MWCNTs) for in vivo distribution study of o-MWCNTs by magnetic resonance imaging (MRI). SPIO labeled o-MWCNTs (((SPIO))o-MWCNTs) were prepared by a hydrothermal reaction process, and characterized by TEM, XRD and magnetometer. ((SPIO))o-MWCNTs exhibited superparamagnetic property, excellent biocompatibility and stability. The intravenously injected ((SPIO))o-MWCNTs were observed in liver, kidney and spleen, while the subcutaneously injected ((SPIO))o-MWCNTs could be only detected in sub mucosa. Most of the intravenously injected ((SPIO))o-MWCNTs could be eliminated from liver, spleen, kidney and sub mucosa on 4 d post injection (P.I.). However, the residual o-MWCNTs could induce 30-40% MRI signal-to-noise ratio changes in these tissues even on 30 d P.I. This in vivo biodistribution and elimination information of o-MWCNTs will greatly facilitate the application of f-CNT based nanoproducts in biomedicine. In addition, the magnetic labeling method provides an approach to investigate the in vivo biodistribution and clearance of other nanomaterials.
关键词[WOS]: MRI CONTRAST AGENTS ;  DRUG-DELIVERY ;  BIODISTRIBUTION ;  CELLS ;  NANOPARTICLES ;  SCAFFOLDS ;  TRACKING ;  ENHANCE ;  FE3O4 ;  DNA
语种: 英语
WOS记录号: WOS:000345603800002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145725
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Calif Los Angeles, Div NanoMed, Dept Med, Los Angeles, CA 90095 USA
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
3.Dalian Univ, Affiliated Zhongshan Hosp, Dept Radiol, Dalian 116001, Peoples R China
4.Dalian Med Univ, Affiliated Hosp 1, Dept Radiol, Dalian 116011, Peoples R China

Recommended Citation:
Li, Ruibin,Wu, Ren'an,Zhao, Liang,et al. In vivo detection of magnetic labeled oxidized multi-walled carbon nanotubes by magnetic resonance imaging[J]. NANOTECHNOLOGY,2014,25(49).
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