中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Ambient temperature nanoelectrospray ion mobility detector for high performance liquid chromatography in determining amines
作者: Chen, Chuang1;  Hou, Keyong1;  Wang, Weiguo1;  Li, Jinghua1;  Li, Haiyang1
关键词: Nanoelectrospray ;  Ion mobility detector ;  High performance liquid chromatography ;  Amines
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2014-09-05
DOI: 10.1016/j.chroma.2014.06.107
卷: 1358, 页:192-198
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: A nanoelectrospray ionization ion mobility spectrometer (nanoESI-IMS) working at ambient pressure and ambient temperature was developed as a detector of high performance liquid chromatography (HPLC) to achieve sensitive detection of amines with no derivatization and meanwhile provide another dimension of separation. The easier desolvation property of the charged droplets formed in nanoESI source enabled complete desolvation of the product ions of sixteen amines and drugs using the nanoESI-IMS at ambient temperature. Working at ambient temperature was good for suppressing the dissociation of thermal volatile ions, such as only the proton adducted molecular ions were observed for morphine in the nanoESI-IMS. Besides, the resolving power of the nanoESI-IMS also showed an increasing tendency as lowering the working temperature, an increment of 19 percent and 10 percent was observed for diethylamine and triethylamine as the temperature dropped from 92 degrees C to 32 degrees C. The resolving power of the nanoESI-IMS at 32 C for the 16 tested compounds was amid 33-44. With the nanoESI-IMS coupled to HPLC, a six-compound mixture including isomers was successfully separated and detected without any derivatization. And linear response ranges of 1 to 20, 0.5 to 20, and 0.8 to 20 mu g ml(-1) and limits of detection of 0.25, 0.15, and 0.17 mu g ml(-1) for triethylamine, diethylamine, and butylamine, respectively, were obtained with the hyphenated system. These results showed the excellent performance of the two-dimensional separation and detection method in direct qualitative and quantitative analyses of amines. (C) 2014 Elsevier B.V. All rights reserved.
关键词[WOS]: ELECTROSPRAY-IONIZATION ;  ALIPHATIC-AMINES ;  MASS-SPECTROMETRY ;  AROMATIC-AMINES ;  BIOGENIC-AMINES ;  ILLICIT DRUGS ;  AIR SAMPLES ;  MICROEXTRACTION ;  DERIVATIZATION ;  WATER
语种: 英语
WOS记录号: WOS:000340979200023
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145728
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China

Recommended Citation:
Chen, Chuang,Hou, Keyong,Wang, Weiguo,et al. Ambient temperature nanoelectrospray ion mobility detector for high performance liquid chromatography in determining amines[J]. JOURNAL OF CHROMATOGRAPHY A,2014,1358:192-198.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Chen, Chuang]'s Articles
 [Hou, Keyong]'s Articles
 [Wang, Weiguo]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Chen, Chuang]‘s Articles
 [Hou, Keyong]‘s Articles
 [Wang, Weiguo]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace