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题名: Synthesis of Chiral Exocyclic Amines by Asymmetric Hydrogenation of Aromatic Quinolin-3-amines
作者: Cai, Xian-Feng1, 2;  Guo, Ran-Ning1;  Chen, Mu-Wang1;  Shi, Lei1;  Zhou, Yong-Gui1
关键词: aromatic amines ;  asymmetric hydrogenation ;  chirality ;  exocyclic amines
刊名: CHEMISTRY-A EUROPEAN JOURNAL
发表日期: 2014-06-10
DOI: 10.1002/chem.201402592
卷: 20, 期:24, 页:7245-7248
收录类别: SCI ;  IC ;  CCR
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Asymmetric hydrogenation of aromatic quinolin-3-amines was successfully developed with up to 94% enantiomeric excess (ee). Introduction of the phthaloyl moiety to the amino group is crucial to eliminate the inhibition effect caused by the substrate and product, to activate the aromatic ring, and to improve the diastereo-selectivity. This new methodology provides direct and facile access to chiral exocyclic amines. Notably, this report is the first on the highly enantioselective hydrogenation of aromatic amines.
关键词[WOS]: IRIDIUM-CATALYZED HYDROGENATION ;  2 CONTIGUOUS STEREOCENTERS ;  ENANTIOSELECTIVE HYDROGENATION ;  HETEROAROMATIC-COMPOUNDS ;  ISOQUINOLINIUM SALTS ;  FACILE ACCESS ;  QUINOLINES ;  QUINOXALINES ;  REDUCTION ;  EFFICIENT
语种: 英语
WOS记录号: WOS:000337617500008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145735
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Dalian Univ Technol, Dept Chem, Dalian 116012, Peoples R China

Recommended Citation:
Cai, Xian-Feng,Guo, Ran-Ning,Chen, Mu-Wang,et al. Synthesis of Chiral Exocyclic Amines by Asymmetric Hydrogenation of Aromatic Quinolin-3-amines[J]. CHEMISTRY-A EUROPEAN JOURNAL,2014,20(24):7245-7248.
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