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题名: Design, simulation and evaluation of improved air amplifier incorporating an ion funnel for nano-ESI MS
作者: Jurcicek, Petr1;  Liu, Lingpeng1;  Zou, Helin1;  An, Zhiqi1;  Xiao, Hongbin2
关键词: ESI ;  nanoelectrospray ;  air amplifier ;  ion focusing ;  ion funnel ;  computational fluid dynamics ;  ion trajectory
刊名: EUROPEAN JOURNAL OF MASS SPECTROMETRY
发表日期: 2014
DOI: 10.1255/ejms.1269
卷: 20, 期:2, 页:143-154
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Physics, Atomic, Molecular & Chemical ;  Spectroscopy
研究领域[WOS]: Physics ;  Spectroscopy
英文摘要: An improved air amplifier design that takes advantage of the combined effects of aerodynamic and electrodynamic focusing was developed to couple a nanoelectrospray ionisation (nano-ESI) source and the heated mass spectrometer inlet to improve the sensitivity of a mass spectrometer. The new design comprises an electrodynamic ion funnel integrated into the main air pathway of the air amplifier to more effectively focus and transmit gas-phase ions from the nano-ESI source into the heated mass spectrometer inlet. Numerical computational fluid dynamics simulations were carried out using a commercial software package, ANSYS FLUENT, to provide more detailed information about the device's performance. The gas flow field as well as the electric field patterns and the Lagrangian ion motion were conveniently simulated using this single package and custom-written, user-defined functions. Experimental results show a nearly five-fold improvement in reserpine ion intensity with the air amplifier operated at a nitrogen gauge pressure of 40 kPa and no direct current (DC) or radiofrequency (RF) potentials applied to the ion funnel when the distance between the electrospray emitter and sampling inlet tube was 24 mm, as compared to direct sample infusion from the same distance without the air amplifier. More importantly, a nearly three-fold additional gain in ion intensity was measured when both DC and RF potentials were co-applied, resulting in more than a 13-fold overall ion intensity gain which could be attributed to the combined air amplifier aerodynamic and ion funnel electrodynamic focusing effect.
关键词[WOS]: IONIZATION-MASS-SPECTROMETRY ;  ELECTROSPRAY-IONIZATION ;  ATMOSPHERIC-PRESSURE ;  VENTURI DEVICE ;  INTERFACE ;  TRANSMISSION ;  FLOW ;  EFFICIENCY
语种: 英语
WOS记录号: WOS:000334729200003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/145743
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ Technol, Key Lab Micronano Syst & Technol Liaoning Prov, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Jurcicek, Petr,Liu, Lingpeng,Zou, Helin,et al. Design, simulation and evaluation of improved air amplifier incorporating an ion funnel for nano-ESI MS[J]. EUROPEAN JOURNAL OF MASS SPECTROMETRY,2014,20(2):143-154.
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